Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2624878..2626466 Replicon chromosome
Accession NZ_CP083051
Organism Klebsiella pneumoniae strain 0213293972

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag K9F37_RS13045 Protein ID WP_004190166.1
Coordinates 2624878..2626200 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag K9F37_RS13050 Protein ID WP_002904790.1
Coordinates 2626200..2626466 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F37_RS13030 (2619934) 2619934..2622435 + 2502 WP_004190161.1 fimbria/pilus outer membrane usher protein -
K9F37_RS13035 (2622423) 2622423..2623427 + 1005 WP_231544198.1 fimbrial protein -
K9F37_RS13040 (2623569) 2623569..2624861 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
K9F37_RS13045 (2624878) 2624878..2626200 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
K9F37_RS13050 (2626200) 2626200..2626466 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K9F37_RS13055 (2626731) 2626731..2627057 - 327 WP_004143476.1 hydroxyisourate hydrolase -
K9F37_RS13060 (2627054) 2627054..2627554 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
K9F37_RS13065 (2627532) 2627532..2628911 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
K9F37_RS13070 (2629257) 2629257..2630411 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
K9F37_RS13075 (2630392) 2630392..2631315 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T216039 WP_004190166.1 NZ_CP083051:c2626200-2624878 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T216039 NZ_CP111111:2061708-2061896 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT216039 WP_002904790.1 NZ_CP083051:c2626466-2626200 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT216039 NZ_CP111111:2061426-2061683 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References