Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 808920..809577 Replicon chromosome
Accession NZ_CP083051
Organism Klebsiella pneumoniae strain 0213293972

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K9F37_RS04010 Protein ID WP_002916310.1
Coordinates 809167..809577 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K9F37_RS04005 Protein ID WP_002916312.1
Coordinates 808920..809186 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F37_RS03980 (804076) 804076..805509 - 1434 WP_023328360.1 6-phospho-beta-glucosidase BglA -
K9F37_RS03985 (805628) 805628..806356 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K9F37_RS03990 (806406) 806406..806717 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K9F37_RS03995 (806881) 806881..807540 + 660 WP_002916317.1 hemolysin III family protein -
K9F37_RS04000 (807691) 807691..808674 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
K9F37_RS04005 (808920) 808920..809186 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K9F37_RS04010 (809167) 809167..809577 + 411 WP_002916310.1 protein YgfX Toxin
K9F37_RS04015 (809584) 809584..810105 - 522 WP_004144730.1 flavodoxin FldB -
K9F37_RS04020 (810206) 810206..811102 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K9F37_RS04025 (811125) 811125..811838 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9F37_RS04030 (811844) 811844..813577 + 1734 WP_023328361.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T216030 WP_002916310.1 NZ_CP083051:809167-809577 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T216030 NZ_CP111073:518277-518627 [Bacillus inaquosorum]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT216030 WP_002916312.1 NZ_CP083051:808920-809186 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216030 NZ_CP111073:517991-518272 [Bacillus inaquosorum]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References