216018

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4177741..4178360 Replicon chromosome
Accession NZ_CP083047
Organism Klebsiella pneumoniae strain 400195-1-18

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K9F24_RS20455 Protein ID WP_002892050.1
Coordinates 4178142..4178360 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K9F24_RS20450 Protein ID WP_002892066.1
Coordinates 4177741..4178115 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F24_RS20440 (4172893) 4172893..4174086 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K9F24_RS20445 (4174109) 4174109..4177255 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K9F24_RS20450 (4177741) 4177741..4178115 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K9F24_RS20455 (4178142) 4178142..4178360 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K9F24_RS20460 (4178519) 4178519..4179085 + 567 WP_002892030.1 maltose O-acetyltransferase -
K9F24_RS20465 (4179057) 4179057..4179197 - 141 WP_004147370.1 hypothetical protein -
K9F24_RS20470 (4179218) 4179218..4179688 + 471 WP_002892026.1 YlaC family protein -
K9F24_RS20475 (4179663) 4179663..4181114 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K9F24_RS20480 (4181215) 4181215..4181913 + 699 WP_004178762.1 GNAT family protein -
K9F24_RS20485 (4181910) 4181910..4182050 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K9F24_RS20490 (4182050) 4182050..4182313 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T216018 WP_002892050.1 NZ_CP083047:4178142-4178360 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T216018 NZ_CP111032:c5198838-5198491 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCTGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGTGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT216018 WP_002892066.1 NZ_CP083047:4177741-4178115 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT216018 NZ_CP111032:c5199099-5198848 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References