Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 112322..113073 Replicon plasmid p1-400195-2-18
Accession NZ_CP083044
Organism Klebsiella pneumoniae strain 400195-2-18

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag K9F25_RS27000 Protein ID WP_014386536.1
Coordinates 112322..112804 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag K9F25_RS27005 Protein ID WP_004902250.1
Coordinates 112795..113073 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F25_RS26980 (K9F25_26915) 108721..109368 - 648 WP_014386537.1 EcsC family protein -
K9F25_RS26985 (K9F25_26920) 109395..110150 - 756 WP_004902235.1 DUF2971 domain-containing protein -
K9F25_RS26990 (K9F25_26925) 110251..110643 - 393 WP_032442757.1 hypothetical protein -
K9F25_RS26995 (K9F25_26930) 110748..111287 - 540 WP_004902239.1 hypothetical protein -
K9F25_RS27000 (K9F25_26935) 112322..112804 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
K9F25_RS27005 (K9F25_26940) 112795..113073 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
K9F25_RS27010 (K9F25_26945) 113192..113404 - 213 WP_004902255.1 hypothetical protein -
K9F25_RS27015 (K9F25_26950) 113512..113853 - 342 WP_004902257.1 hypothetical protein -
K9F25_RS27020 (K9F25_26955) 114683..115141 - 459 WP_014386535.1 hypothetical protein -
K9F25_RS27025 (K9F25_26960) 115794..116249 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
K9F25_RS27030 (K9F25_26965) 116321..116686 + 366 WP_004200999.1 mercuric ion transporter MerT -
K9F25_RS27035 (K9F25_26970) 116702..116977 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
K9F25_RS27040 (K9F25_26975) 117005..117430 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..254008 254008


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T216003 WP_014386536.1 NZ_CP083044:c112804-112322 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T216003 NZ_CP111030:c150887-150606 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGTAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT216003 WP_004902250.1 NZ_CP083044:c113073-112795 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT216003 NZ_CP111030:c151111-150884 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References