Detailed information of TA system TA215995

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2805181..2806769
• Replicon: chromosome
• Accession: NZ_CP083043
• Organism: Klebsiella pneumoniae strain 400195-2-18

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K9F25_RS13870
• Protein ID: WP_004179815.1
• Coordinates: 2805181..2806503 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K9F25_RS13875
• Protein ID: WP_004176198.1
• Coordinates: 2806503..2806769 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9F25_RS13855 (2800237)	2800237..2802738	+	2502	WP_004179823.1	fimbria/pilus outer membrane usher protein	-
K9F25_RS13860 (2802726)	2802726..2803730	+	1005	WP_004179822.1	fimbrial protein	-
K9F25_RS13865 (2803872)	2803872..2805164	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
K9F25_RS13870 (2805181)	2805181..2806503	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
K9F25_RS13875 (2806503)	2806503..2806769	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K9F25_RS13880 (2807035)	2807035..2807361	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
K9F25_RS13885 (2807358)	2807358..2807858	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
K9F25_RS13890 (2807836)	2807836..2809215	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
K9F25_RS13895 (2809561)	2809561..2810715	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
K9F25_RS13900 (2810696)	2810696..2811619	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T215995 WP_004179815.1 NZ_CP083043:c2806503-2805181 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T215995 NZ_CP111029:c2248715-2248431 [Salmonella sp. 2018103]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACAACACAGAAGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT215995 WP_004176198.1 NZ_CP083043:c2806769-2806503 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT215995 NZ_CP111029:c2248953-2248705 [Salmonella sp. 2018103]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA