Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 348708..349294 Replicon chromosome
Accession NZ_CP083043
Organism Klebsiella pneumoniae strain 400195-2-18

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag K9F25_RS01605 Protein ID WP_002920800.1
Coordinates 348926..349294 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag K9F25_RS01600 Protein ID WP_004174006.1
Coordinates 348708..348929 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F25_RS01580 (344865) 344865..345791 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
K9F25_RS01585 (345788) 345788..347065 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
K9F25_RS01590 (347062) 347062..347829 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
K9F25_RS01595 (347831) 347831..348544 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
K9F25_RS01600 (348708) 348708..348929 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K9F25_RS01605 (348926) 348926..349294 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K9F25_RS01610 (349567) 349567..350883 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
K9F25_RS01615 (350990) 350990..351877 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
K9F25_RS01620 (351874) 351874..352719 + 846 WP_004181473.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
K9F25_RS01625 (352721) 352721..353791 + 1071 WP_043906884.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 343694..354528 10834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T215985 WP_002920800.1 NZ_CP083043:348926-349294 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T215985 NZ_CP111008:c3991706-3991599 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT215985 WP_004174006.1 NZ_CP083043:348708-348929 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT215985 NZ_CP111008:3991755-3991821 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References