Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4427032..4427819 | Replicon | chromosome |
| Accession | NZ_CP083036 | ||
| Organism | Klebsiella pneumoniae strain 4906.28 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A377E3D6 |
| Locus tag | K9F35_RS22000 | Protein ID | WP_001194695.1 |
| Coordinates | 4427442..4427819 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | K9F35_RS21995 | Protein ID | WP_053266522.1 |
| Coordinates | 4427032..4427391 (+) | Length | 120 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9F35_RS21950 (4422271) | 4422271..4422723 | + | 453 | WP_001020418.1 | hypothetical protein | - |
| K9F35_RS21955 (4422720) | 4422720..4423172 | + | 453 | WP_016245672.1 | hypothetical protein | - |
| K9F35_RS21960 (4423235) | 4423235..4423777 | + | 543 | WP_001104018.1 | DUF4339 domain-containing protein | - |
| K9F35_RS21965 (4423837) | 4423837..4424289 | + | 453 | WP_020837115.1 | IrmA family protein | - |
| K9F35_RS21970 (4424366) | 4424366..4424599 | + | 234 | WP_001114682.1 | DUF905 domain-containing protein | - |
| K9F35_RS21975 (4424719) | 4424719..4425537 | + | 819 | WP_001614356.1 | DUF932 domain-containing protein | - |
| K9F35_RS21980 (4425805) | 4425805..4426275 | + | 471 | WP_000131762.1 | antirestriction protein | - |
| K9F35_RS21985 (4426287) | 4426287..4426766 | + | 480 | WP_000437750.1 | DNA repair protein RadC | - |
| K9F35_RS21990 (4426787) | 4426787..4427008 | + | 222 | WP_044068431.1 | DUF987 domain-containing protein | - |
| K9F35_RS21995 (4427032) | 4427032..4427391 | + | 360 | WP_053266522.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| K9F35_RS22000 (4427442) | 4427442..4427819 | + | 378 | WP_001194695.1 | TA system toxin CbtA family protein | Toxin |
| K9F35_RS22005 (4427816) | 4427816..4428307 | + | 492 | WP_000777682.1 | DUF5983 family protein | - |
| K9F35_RS22010 (4428347) | 4428347..4428541 | + | 195 | WP_032155094.1 | DUF957 domain-containing protein | - |
| K9F35_RS22015 (4428622) | 4428622..4429466 | + | 845 | Protein_4332 | DUF4942 domain-containing protein | - |
| K9F35_RS22025 (4429810) | 4429810..4430541 | - | 732 | WP_004152034.1 | DNA polymerase III subunit epsilon | - |
| K9F35_RS22030 (4430606) | 4430606..4431073 | + | 468 | WP_002889686.1 | ribonuclease HI | - |
| K9F35_RS22035 (4431070) | 4431070..4431792 | - | 723 | WP_032419379.1 | class I SAM-dependent methyltransferase | - |
| K9F35_RS22040 (4431825) | 4431825..4432580 | + | 756 | WP_032419380.1 | hydroxyacylglutathione hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14180.97 Da Isoelectric Point: 7.4209
>T215981 WP_001194695.1 NZ_CP083036:4427442-4427819 [Klebsiella pneumoniae]
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
Download Length: 378 bp
>T215981 NZ_CP111008:c3526660-3526262 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13109.09 Da Isoelectric Point: 7.3717
>AT215981 WP_053266522.1 NZ_CP083036:4427032-4427391 [Klebsiella pneumoniae]
MSNKTPIVNHDITEPWWGLKRSITPCFGARLVQAGNCLHYLADRASITGQFSDAVLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA
MSNKTPIVNHDITEPWWGLKRSITPCFGARLVQAGNCLHYLADRASITGQFSDAVLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA
Download Length: 360 bp
>AT215981 NZ_CP111008:c3526956-3526663 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|