Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4174494..4175113 Replicon chromosome
Accession NZ_CP083036
Organism Klebsiella pneumoniae strain 4906.28

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K9F35_RS20735 Protein ID WP_002892050.1
Coordinates 4174895..4175113 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K9F35_RS20730 Protein ID WP_002892066.1
Coordinates 4174494..4174868 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F35_RS20720 (4169646) 4169646..4170839 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K9F35_RS20725 (4170862) 4170862..4174008 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K9F35_RS20730 (4174494) 4174494..4174868 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K9F35_RS20735 (4174895) 4174895..4175113 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K9F35_RS20740 (4175272) 4175272..4175838 + 567 WP_002892030.1 maltose O-acetyltransferase -
K9F35_RS20745 (4175810) 4175810..4175950 - 141 WP_004147370.1 hypothetical protein -
K9F35_RS20750 (4175971) 4175971..4176441 + 471 WP_002892026.1 YlaC family protein -
K9F35_RS20755 (4176416) 4176416..4177867 - 1452 WP_032419337.1 PLP-dependent aminotransferase family protein -
K9F35_RS20760 (4177968) 4177968..4178666 + 699 WP_002892021.1 GNAT family protein -
K9F35_RS20765 (4178663) 4178663..4178803 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K9F35_RS20770 (4178803) 4178803..4179066 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T215980 WP_002892050.1 NZ_CP083036:4174895-4175113 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T215980 NZ_CP083036:4174895-4175113 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT215980 WP_002892066.1 NZ_CP083036:4174494-4174868 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT215980 NZ_CP083036:4174494-4174868 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References