Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2769965..2771553 Replicon chromosome
Accession NZ_CP083036
Organism Klebsiella pneumoniae strain 4906.28

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K9F35_RS13890 Protein ID WP_004184027.1
Coordinates 2769965..2771287 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K9F35_RS13895 Protein ID WP_004176198.1
Coordinates 2771287..2771553 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F35_RS13875 (2765021) 2765021..2767522 + 2502 WP_117051210.1 fimbria/pilus outer membrane usher protein -
K9F35_RS13880 (2767510) 2767510..2768514 + 1005 WP_016946380.1 fimbrial protein -
K9F35_RS13885 (2768656) 2768656..2769948 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
K9F35_RS13890 (2769965) 2769965..2771287 - 1323 WP_004184027.1 type II toxin-antitoxin system HipA family toxin Toxin
K9F35_RS13895 (2771287) 2771287..2771553 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K9F35_RS13900 (2771819) 2771819..2772145 - 327 WP_004215084.1 hydroxyisourate hydrolase -
K9F35_RS13905 (2772142) 2772142..2772642 - 501 WP_032418978.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
K9F35_RS13910 (2772620) 2772620..2773999 - 1380 WP_032418979.1 nucleobase:cation symporter-2 family protein -
K9F35_RS13915 (2774345) 2774345..2775499 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
K9F35_RS13920 (2775480) 2775480..2776403 - 924 WP_032418980.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T215978 WP_004184027.1 NZ_CP083036:c2771287-2769965 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T215978 NZ_CP111008:2472530-2472637 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT215978 WP_004176198.1 NZ_CP083036:c2771553-2771287 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT215978 NZ_CP111008:c2472483-2472417 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References