Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 777923..778580 Replicon chromosome
Accession NZ_CP083036
Organism Klebsiella pneumoniae strain 4906.28

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K9F35_RS03855 Protein ID WP_002916310.1
Coordinates 778170..778580 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K9F35_RS03850 Protein ID WP_002916312.1
Coordinates 777923..778189 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F35_RS03825 (773079) 773079..774512 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
K9F35_RS03830 (774631) 774631..775359 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K9F35_RS03835 (775409) 775409..775720 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K9F35_RS03840 (775884) 775884..776543 + 660 WP_002916317.1 hemolysin III family protein -
K9F35_RS03845 (776694) 776694..777677 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K9F35_RS03850 (777923) 777923..778189 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K9F35_RS03855 (778170) 778170..778580 + 411 WP_002916310.1 protein YgfX Toxin
K9F35_RS03860 (778587) 778587..779108 - 522 WP_004144730.1 flavodoxin FldB -
K9F35_RS03865 (779209) 779209..780105 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K9F35_RS03870 (780128) 780128..780841 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9F35_RS03875 (780847) 780847..782580 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T215968 WP_002916310.1 NZ_CP083036:778170-778580 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215968 NZ_CP111008:c964625-964296 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215968 WP_002916312.1 NZ_CP083036:777923-778189 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215968 NZ_CP111008:c964963-964646 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References