Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 133083..133606 | Replicon | plasmid p2-5208.51-NDM1 |
| Accession | NZ_CP083034 | ||
| Organism | Klebsiella pneumoniae strain 5208.51 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | V5RNQ6 |
| Locus tag | K9F36_RS27235 | Protein ID | WP_015632464.1 |
| Coordinates | 133083..133388 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | V5RQR8 |
| Locus tag | K9F36_RS27240 | Protein ID | WP_015632465.1 |
| Coordinates | 133388..133606 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9F36_RS27190 (K9F36_27160) | 128113..128541 | - | 429 | WP_015632456.1 | plasmid partitioning/stability family protein | - |
| K9F36_RS27195 (K9F36_27165) | 128534..129514 | - | 981 | WP_015632457.1 | plasmid segregation protein ParM | - |
| K9F36_RS27200 (K9F36_27170) | 129875..130057 | + | 183 | WP_015632458.1 | type II toxin-antitoxin system HicA family toxin | - |
| K9F36_RS27205 (K9F36_27175) | 130083..130526 | + | 444 | WP_015632459.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| K9F36_RS27210 (K9F36_27180) | 130732..130854 | - | 123 | Protein_134 | transcriptional regulator | - |
| K9F36_RS27215 (K9F36_27185) | 130868..131095 | - | 228 | WP_016162072.1 | hypothetical protein | - |
| K9F36_RS27220 | 131327..131782 | + | 456 | WP_015632461.1 | helix-turn-helix domain-containing protein | - |
| K9F36_RS27225 | 132034..132129 | - | 96 | Protein_137 | IS1 family transposase | - |
| K9F36_RS27230 (K9F36_27200) | 132594..132971 | - | 378 | WP_016162069.1 | hypothetical protein | - |
| K9F36_RS27235 (K9F36_27205) | 133083..133388 | - | 306 | WP_015632464.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| K9F36_RS27240 (K9F36_27210) | 133388..133606 | - | 219 | WP_015632465.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| K9F36_RS27245 (K9F36_27215) | 133792..134817 | + | 1026 | WP_015632466.1 | IS110 family transposase | - |
| K9F36_RS27250 (K9F36_27220) | 135112..135597 | + | 486 | Protein_142 | IS5 family transposase | - |
| K9F36_RS27255 (K9F36_27225) | 135761..136192 | + | 432 | WP_015632467.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| K9F36_RS27260 (K9F36_27230) | 136192..137463 | + | 1272 | WP_016162068.1 | Y-family DNA polymerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | rmtF / ARR-3 / blaNDM-1 | htpB | 1..137856 | 137856 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11361.90 Da Isoelectric Point: 5.5252
>T215966 WP_015632464.1 NZ_CP083034:c133388-133083 [Klebsiella pneumoniae]
MQFTVYEYTRESHYRLFVDVQSDIVETPGRRIVIPLLESHHLSEKVNQQLFPVVSVNGKEYRAVTSELSGVSVSVIGDAV
ADLSHEANAIKNALNLMFWGI
MQFTVYEYTRESHYRLFVDVQSDIVETPGRRIVIPLLESHHLSEKVNQQLFPVVSVNGKEYRAVTSELSGVSVSVIGDAV
ADLSHEANAIKNALNLMFWGI
Download Length: 306 bp
>T215966 NZ_CP111008:699917-700324 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8194.13 Da Isoelectric Point: 6.2224
>AT215966 WP_015632465.1 NZ_CP083034:c133606-133388 [Klebsiella pneumoniae]
MKHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW
MKHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW
Download Length: 219 bp
>AT215966 NZ_CP111008:699670-699936 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6C0ND19 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6C0L1T7 |