Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 138004..138749 | Replicon | plasmid p1-5208.51 |
| Accession | NZ_CP083033 | ||
| Organism | Klebsiella pneumoniae strain 5208.51 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A331KSM6 |
| Locus tag | K9F36_RS26295 | Protein ID | WP_032408901.1 |
| Coordinates | 138258..138749 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | - |
| Locus tag | K9F36_RS26290 | Protein ID | WP_014386183.1 |
| Coordinates | 138004..138270 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9F36_RS26240 (K9F36_26220) | 133556..133969 | - | 414 | WP_013023817.1 | helix-turn-helix domain-containing protein | - |
| K9F36_RS26245 (K9F36_26225) | 133970..134248 | - | 279 | WP_004152721.1 | helix-turn-helix transcriptional regulator | - |
| K9F36_RS26250 (K9F36_26230) | 134238..134558 | - | 321 | WP_014386190.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K9F36_RS26255 (K9F36_26235) | 134639..134863 | - | 225 | WP_014386189.1 | hypothetical protein | - |
| K9F36_RS26260 (K9F36_26240) | 134874..135086 | - | 213 | WP_014386188.1 | hypothetical protein | - |
| K9F36_RS26265 (K9F36_26245) | 135148..135474 | - | 327 | WP_014386187.1 | hypothetical protein | - |
| K9F36_RS26270 (K9F36_26250) | 136111..136461 | - | 351 | WP_014386186.1 | hypothetical protein | - |
| K9F36_RS26275 (K9F36_26255) | 136458..136730 | - | 273 | WP_032408902.1 | hypothetical protein | - |
| K9F36_RS26280 (K9F36_26260) | 136920..137405 | + | 486 | WP_014386185.1 | hypothetical protein | - |
| K9F36_RS26285 (K9F36_26265) | 137649..137807 | - | 159 | WP_014386184.1 | type I toxin-antitoxin system Hok family toxin | - |
| K9F36_RS26290 (K9F36_26270) | 138004..138270 | + | 267 | WP_014386183.1 | DUF1778 domain-containing protein | Antitoxin |
| K9F36_RS26295 (K9F36_26275) | 138258..138749 | + | 492 | WP_032408901.1 | GNAT family N-acetyltransferase | Toxin |
| K9F36_RS26300 (K9F36_26280) | 139190..139441 | - | 252 | WP_032408900.1 | aldo/keto reductase | - |
| K9F36_RS26305 (K9F36_26285) | 139638..141230 | - | 1593 | Protein_154 | IS66 family transposase | - |
| K9F36_RS26310 (K9F36_26290) | 141261..141611 | - | 351 | WP_014386180.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| K9F36_RS26315 (K9F36_26295) | 141608..142048 | - | 441 | WP_014386179.1 | transposase | - |
| K9F36_RS26320 (K9F36_26300) | 142310..143065 | - | 756 | WP_032408898.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..182759 | 182759 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17667.46 Da Isoelectric Point: 8.8757
>T215964 WP_032408901.1 NZ_CP083033:138258-138749 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT
Download Length: 492 bp
>T215964 NZ_CP111008:506285-506599 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10090.66 Da Isoelectric Point: 5.1169
>AT215964 WP_014386183.1 NZ_CP083033:138004-138270 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK
Download Length: 267 bp
>AT215964 NZ_CP111008:506596-507012 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|