Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3959861..3960480 Replicon chromosome
Accession NZ_CP083032
Organism Klebsiella pneumoniae strain 5208.51

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K9F36_RS19575 Protein ID WP_002892050.1
Coordinates 3960262..3960480 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K9F36_RS19570 Protein ID WP_002892066.1
Coordinates 3959861..3960235 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F36_RS19560 (3955013) 3955013..3956206 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K9F36_RS19565 (3956229) 3956229..3959375 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K9F36_RS19570 (3959861) 3959861..3960235 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K9F36_RS19575 (3960262) 3960262..3960480 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K9F36_RS19580 (3960643) 3960643..3961209 + 567 WP_002892030.1 maltose O-acetyltransferase -
K9F36_RS19585 (3961181) 3961181..3961321 - 141 WP_004147370.1 hypothetical protein -
K9F36_RS19590 (3961342) 3961342..3961812 + 471 WP_040182126.1 YlaC family protein -
K9F36_RS19595 (3961787) 3961787..3963238 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K9F36_RS19600 (3963339) 3963339..3964037 + 699 WP_002892021.1 GNAT family protein -
K9F36_RS19605 (3964034) 3964034..3964174 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K9F36_RS19610 (3964174) 3964174..3964437 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T215958 WP_002892050.1 NZ_CP083032:3960262-3960480 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T215958 NZ_CP111004:c4116518-4116168 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT215958 WP_002892066.1 NZ_CP083032:3959861-3960235 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT215958 NZ_CP111004:c4116763-4116512 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References