Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 786166..786823 Replicon chromosome
Accession NZ_CP083032
Organism Klebsiella pneumoniae strain 5208.51

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K9F36_RS03920 Protein ID WP_002916310.1
Coordinates 786413..786823 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K9F36_RS03915 Protein ID WP_002916312.1
Coordinates 786166..786432 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F36_RS03890 (781322) 781322..782755 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K9F36_RS03895 (782874) 782874..783602 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K9F36_RS03900 (783652) 783652..783963 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K9F36_RS03905 (784127) 784127..784786 + 660 WP_002916317.1 hemolysin III family protein -
K9F36_RS03910 (784937) 784937..785920 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
K9F36_RS03915 (786166) 786166..786432 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K9F36_RS03920 (786413) 786413..786823 + 411 WP_002916310.1 protein YgfX Toxin
K9F36_RS03925 (786830) 786830..787351 - 522 WP_004144730.1 flavodoxin FldB -
K9F36_RS03930 (787452) 787452..788348 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K9F36_RS03935 (788371) 788371..789084 + 714 WP_231538026.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9F36_RS03940 (789090) 789090..790823 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T215948 WP_002916310.1 NZ_CP083032:786413-786823 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215948 NZ_CP111004:c2233141-2232965 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215948 WP_002916312.1 NZ_CP083032:786166-786432 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215948 NZ_CP111004:c2232919-2232503 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References