Detailed information of TA system TA215939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2796826..2798414
• Replicon: chromosome
• Accession: NZ_CP083026
• Organism: Klebsiella pneumoniae strain 6604.68

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K9F26_RS13885
• Protein ID: WP_004184027.1
• Coordinates: 2796826..2798148 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K9F26_RS13890
• Protein ID: WP_004176198.1
• Coordinates: 2798148..2798414 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9F26_RS13870 (2791882)	2791882..2794383	+	2502	WP_032418977.1	fimbria/pilus outer membrane usher protein	-
K9F26_RS13875 (2794371)	2794371..2795375	+	1005	WP_016946380.1	fimbrial protein	-
K9F26_RS13880 (2795517)	2795517..2796809	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
K9F26_RS13885 (2796826)	2796826..2798148	-	1323	WP_004184027.1	type II toxin-antitoxin system HipA family toxin	Toxin
K9F26_RS13890 (2798148)	2798148..2798414	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K9F26_RS13895 (2798680)	2798680..2799006	-	327	WP_004215084.1	hydroxyisourate hydrolase	-
K9F26_RS13900 (2799003)	2799003..2799503	-	501	WP_032418978.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
K9F26_RS13905 (2799481)	2799481..2800860	-	1380	WP_032418979.1	nucleobase:cation symporter-2 family protein	-
K9F26_RS13910 (2801206)	2801206..2802360	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
K9F26_RS13915 (2802341)	2802341..2803264	-	924	WP_032418980.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49139.47 Da
• Isoelectric Point: 7.5367

>T215939 WP_004184027.1 NZ_CP083026:c2798148-2796826 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T215939 NZ_CP111004:829649-829984 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT215939 WP_004176198.1 NZ_CP083026:c2798414-2798148 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT215939 NZ_CP111004:829401-829649 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA