Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5033724..5035405 Replicon chromosome
Accession NZ_CP083021
Organism Klebsiella pneumoniae strain 6611.48

Toxin (Protein)


Gene name mosT Uniprot ID J2XCI1
Locus tag K9F27_RS24750 Protein ID WP_004146663.1
Coordinates 5033724..5034641 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag K9F27_RS24755 Protein ID WP_032418188.1
Coordinates 5034647..5035405 (-) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F27_RS24730 (5029030) 5029030..5030550 + 1521 WP_032418186.1 sugar ABC transporter ATP-binding protein -
K9F27_RS24735 (5030547) 5030547..5031545 + 999 WP_002885172.1 ribose ABC transporter permease -
K9F27_RS24740 (5031576) 5031576..5032517 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
K9F27_RS24745 (5032592) 5032592..5033599 + 1008 WP_032418187.1 carbohydrate kinase family protein -
K9F27_RS24750 (5033724) 5033724..5034641 - 918 WP_004146663.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
K9F27_RS24755 (5034647) 5034647..5035405 - 759 WP_032418188.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
K9F27_RS24760 (5035491) 5035491..5036219 - 729 WP_004210017.1 response regulator transcription factor -
K9F27_RS24765 (5036492) 5036492..5038639 + 2148 WP_077598926.1 formate dehydrogenase subunit alpha -
K9F27_RS24770 (5038636) 5038636..5038779 - 144 WP_022631365.1 hypothetical protein -
K9F27_RS24775 (5038985) 5038985..5039671 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34659.10 Da        Isoelectric Point: 5.4707

>T215925 WP_004146663.1 NZ_CP083021:c5034641-5033724 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T215925 NZ_CP110999:3533129-3533407 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28620.99 Da        Isoelectric Point: 10.0001

>AT215925 WP_032418188.1 NZ_CP083021:c5035405-5034647 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPETLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT215925 NZ_CP110999:3532866-3533126 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB J2XCI1


Antitoxin

Source ID Structure

References