Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4137501..4138120 Replicon chromosome
Accession NZ_CP083016
Organism Klebsiella pneumoniae strain 6709.15-I

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K9F34_RS20400 Protein ID WP_002892050.1
Coordinates 4137902..4138120 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K9F34_RS20395 Protein ID WP_002892066.1
Coordinates 4137501..4137875 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F34_RS20385 (4132653) 4132653..4133846 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K9F34_RS20390 (4133869) 4133869..4137015 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K9F34_RS20395 (4137501) 4137501..4137875 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K9F34_RS20400 (4137902) 4137902..4138120 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K9F34_RS20405 (4138279) 4138279..4138845 + 567 WP_002892030.1 maltose O-acetyltransferase -
K9F34_RS20410 (4138817) 4138817..4138957 - 141 WP_004147370.1 hypothetical protein -
K9F34_RS20415 (4138978) 4138978..4139448 + 471 WP_002892026.1 YlaC family protein -
K9F34_RS20420 (4139423) 4139423..4140874 - 1452 WP_032419337.1 PLP-dependent aminotransferase family protein -
K9F34_RS20425 (4140975) 4140975..4141673 + 699 WP_002892021.1 GNAT family protein -
K9F34_RS20430 (4141670) 4141670..4141810 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K9F34_RS20435 (4141810) 4141810..4142073 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T215905 WP_002892050.1 NZ_CP083016:4137902-4138120 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T215905 NZ_CP110998:107712-108017 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT215905 WP_002892066.1 NZ_CP083016:4137501-4137875 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT215905 NZ_CP110998:107492-107710 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References