Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 800266..800923 Replicon chromosome
Accession NZ_CP083016
Organism Klebsiella pneumoniae strain 6709.15-I

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K9F34_RS03995 Protein ID WP_002916310.1
Coordinates 800513..800923 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K9F34_RS03990 Protein ID WP_002916312.1
Coordinates 800266..800532 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F34_RS03965 (795422) 795422..796855 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
K9F34_RS03970 (796974) 796974..797702 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K9F34_RS03975 (797752) 797752..798063 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K9F34_RS03980 (798227) 798227..798886 + 660 WP_002916317.1 hemolysin III family protein -
K9F34_RS03985 (799037) 799037..800020 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K9F34_RS03990 (800266) 800266..800532 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K9F34_RS03995 (800513) 800513..800923 + 411 WP_002916310.1 protein YgfX Toxin
K9F34_RS04000 (800930) 800930..801451 - 522 WP_004144730.1 flavodoxin FldB -
K9F34_RS04005 (801552) 801552..802448 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K9F34_RS04010 (802471) 802471..803184 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9F34_RS04015 (803190) 803190..804923 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T215893 WP_002916310.1 NZ_CP083016:800513-800923 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215893 NZ_CP110996:c3210778-3210404 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215893 WP_002916312.1 NZ_CP083016:800266-800532 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215893 NZ_CP110996:c3211236-3210868 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References