Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4151825..4152444 Replicon chromosome
Accession NZ_CP083011
Organism Klebsiella pneumoniae strain 6710.71

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K9F28_RS20520 Protein ID WP_002892050.1
Coordinates 4152226..4152444 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K9F28_RS20515 Protein ID WP_002892066.1
Coordinates 4151825..4152199 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F28_RS20505 (4146977) 4146977..4148170 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K9F28_RS20510 (4148193) 4148193..4151339 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K9F28_RS20515 (4151825) 4151825..4152199 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K9F28_RS20520 (4152226) 4152226..4152444 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K9F28_RS20525 (4152603) 4152603..4153169 + 567 WP_002892030.1 maltose O-acetyltransferase -
K9F28_RS20530 (4153141) 4153141..4153281 - 141 WP_004147370.1 hypothetical protein -
K9F28_RS20535 (4153302) 4153302..4153772 + 471 WP_002892026.1 YlaC family protein -
K9F28_RS20540 (4153747) 4153747..4155198 - 1452 WP_032419337.1 PLP-dependent aminotransferase family protein -
K9F28_RS20545 (4155299) 4155299..4155997 + 699 WP_002892021.1 GNAT family protein -
K9F28_RS20550 (4155994) 4155994..4156134 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K9F28_RS20555 (4156134) 4156134..4156397 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T215887 WP_002892050.1 NZ_CP083011:4152226-4152444 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T215887 NZ_CP110996:c1711493-1711086 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT215887 WP_002892066.1 NZ_CP083011:4151825-4152199 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT215887 NZ_CP110996:c1711740-1711474 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References