Detailed information of TA system TA215885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2797615..2799203
• Replicon: chromosome
• Accession: NZ_CP083011
• Organism: Klebsiella pneumoniae strain 6710.71

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K9F28_RS13920
• Protein ID: WP_004184027.1
• Coordinates: 2797615..2798937 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K9F28_RS13925
• Protein ID: WP_004176198.1
• Coordinates: 2798937..2799203 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9F28_RS13905 (2792671)	2792671..2795172	+	2502	WP_032418977.1	fimbria/pilus outer membrane usher protein	-
K9F28_RS13910 (2795160)	2795160..2796164	+	1005	WP_016946380.1	fimbrial protein	-
K9F28_RS13915 (2796306)	2796306..2797598	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
K9F28_RS13920 (2797615)	2797615..2798937	-	1323	WP_004184027.1	type II toxin-antitoxin system HipA family toxin	Toxin
K9F28_RS13925 (2798937)	2798937..2799203	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K9F28_RS13930 (2799469)	2799469..2799795	-	327	WP_004215084.1	hydroxyisourate hydrolase	-
K9F28_RS13935 (2799792)	2799792..2800292	-	501	WP_032418978.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
K9F28_RS13940 (2800270)	2800270..2801649	-	1380	WP_032418979.1	nucleobase:cation symporter-2 family protein	-
K9F28_RS13945 (2801995)	2801995..2803149	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
K9F28_RS13950 (2803130)	2803130..2804053	-	924	WP_032418980.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49139.47 Da
• Isoelectric Point: 7.5367

>T215885 WP_004184027.1 NZ_CP083011:c2798937-2797615 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T215885 NZ_CP110996:c787673-787422 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT215885 WP_004176198.1 NZ_CP083011:c2799203-2798937 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT215885 NZ_CP110996:c787425-787171 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA