Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2586568..2587214 Replicon chromosome
Accession NC_008149
Organism Yersinia pestis Nepal516

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag YPN_RS12160 Protein ID WP_002214976.1
Coordinates 2586568..2586750 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag YPN_RS12165 Protein ID WP_002211129.1
Coordinates 2586795..2587214 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPN_RS12125 2581954..2582424 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
YPN_RS12130 2582430..2583431 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
YPN_RS12135 2583428..2583844 + 417 WP_002211134.1 flagellar motor switch protein FliN -
YPN_RS12140 2583844..2584380 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
YPN_RS12145 2584461..2585201 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
YPN_RS12150 2585307..2585576 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
YPN_RS12155 2585579..2586361 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
YPN_RS12160 2586568..2586750 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
YPN_RS12165 2586795..2587214 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
YPN_RS12170 2587472..2588431 - 960 WP_002223882.1 sugar kinase -
YPN_RS12175 2588480..2589502 - 1023 WP_002214974.1 ABC transporter permease -
YPN_RS12180 2589505..2591082 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
YPN_RS12185 2591148..2592143 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T21588 WP_002214976.1 NC_008149:2586568-2586750 [Yersinia pestis Nepal516]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T21588 NC_008149:2586568-2586750 [Yersinia pestis Nepal516]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT21588 WP_002211129.1 NC_008149:2586795-2587214 [Yersinia pestis Nepal516]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT21588 NC_008149:2586795-2587214 [Yersinia pestis Nepal516]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References