Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 322531..323117 Replicon chromosome
Accession NZ_CP083011
Organism Klebsiella pneumoniae strain 6710.71

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag K9F28_RS01495 Protein ID WP_002920800.1
Coordinates 322749..323117 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag K9F28_RS01490 Protein ID WP_004174006.1
Coordinates 322531..322752 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F28_RS01470 (318688) 318688..319614 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
K9F28_RS01475 (319611) 319611..320888 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
K9F28_RS01480 (320885) 320885..321652 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
K9F28_RS01485 (321654) 321654..322367 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
K9F28_RS01490 (322531) 322531..322752 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K9F28_RS01495 (322749) 322749..323117 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K9F28_RS01500 (323390) 323390..324706 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
K9F28_RS01505 (324813) 324813..325700 + 888 WP_032418302.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
K9F28_RS01510 (325697) 325697..326542 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
K9F28_RS01515 (326544) 326544..327614 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 319611..331139 11528


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T215874 WP_002920800.1 NZ_CP083011:322749-323117 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T215874 NZ_CP110988:2684725-2684832 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT215874 WP_004174006.1 NZ_CP083011:322531-322752 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT215874 NZ_CP110988:c2684678-2684612 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References