Detailed information of TA system TA021587

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2041913..2042879
• Replicon: chromosome
• Accession: NC_008149
• Organism: Yersinia pestis Nepal516

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: YPN_RS09570
• Protein ID: WP_002210981.1
• Coordinates: 2042421..2042879 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: YPN_RS09565
• Protein ID: WP_002210982.1
• Coordinates: 2041913..2042359 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPN_RS09545	2037502..2038476	-	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
YPN_RS09550	2038639..2039142	+	504	WP_002210984.1	thiol peroxidase	-
YPN_RS09555	2039395..2039853	+	459	WP_002213775.1	IS200/IS605-like element IS1541B family transposase	-
YPN_RS09560	2040000..2041577	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
YPN_RS09565	2041913..2042359	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
YPN_RS09570	2042421..2042879	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
YPN_RS09575	2042889..2043950	-	1062	WP_002210980.1	YcjF family protein	-
YPN_RS09580	2043947..2045344	-	1398	WP_002210979.1	YcjX family protein	-
YPN_RS09585	2045325..2045567	-	243	WP_002216375.1	phage shock protein PspD	-
YPN_RS09590	2045652..2046011	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
YPN_RS09595	2046011..2046238	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
YPN_RS09600	2046400..2047065	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2039395..2039853	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T21587 WP_002210981.1 NC_008149:2042421-2042879 [Yersinia pestis Nepal516]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T21587 NC_008149:2042421-2042879 [Yersinia pestis Nepal516]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT21587 WP_002210982.1 NC_008149:2041913-2042359 [Yersinia pestis Nepal516]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT21587 NC_008149:2041913-2042359 [Yersinia pestis Nepal516]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1