215869

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4844932..4845448 Replicon chromosome
Accession NZ_CP083007
Organism Klebsiella pneumoniae strain 6711.43

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K9F29_RS23975 Protein ID WP_002886902.1
Coordinates 4844932..4845216 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K9F29_RS23980 Protein ID WP_002886901.1
Coordinates 4845206..4845448 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F29_RS23950 (K9F29_23935) 4840416..4840679 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
K9F29_RS23955 (K9F29_23940) 4840809..4840982 + 174 WP_002886906.1 hypothetical protein -
K9F29_RS23960 (K9F29_23945) 4840985..4841728 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K9F29_RS23965 (K9F29_23950) 4842085..4844223 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K9F29_RS23970 (K9F29_23955) 4844464..4844928 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K9F29_RS23975 (K9F29_23960) 4844932..4845216 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9F29_RS23980 (K9F29_23965) 4845206..4845448 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K9F29_RS23985 (K9F29_23970) 4845526..4847436 - 1911 WP_004152270.1 PRD domain-containing protein -
K9F29_RS23990 (K9F29_23975) 4847459..4848613 - 1155 WP_002886900.1 lactonase family protein -
K9F29_RS23995 (K9F29_23980) 4848679..4849419 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T215869 WP_002886902.1 NZ_CP083007:c4845216-4844932 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T215869 NZ_CP110988:1805897-1806151 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT215869 WP_002886901.1 NZ_CP083007:c4845448-4845206 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT215869 NZ_CP110988:1805649-1805900 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References