Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1107660..1108280 Replicon chromosome
Accession NC_008149
Organism Yersinia pestis Nepal516

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag YPN_RS05105 Protein ID WP_002208622.1
Coordinates 1107660..1107863 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag YPN_RS05110 Protein ID WP_002218472.1
Coordinates 1107912..1108280 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPN_RS05080 1102682..1103020 + 339 WP_002208627.1 P-II family nitrogen regulator -
YPN_RS05085 1103060..1104349 + 1290 WP_002228344.1 ammonium transporter AmtB -
YPN_RS05090 1104609..1105469 - 861 WP_002208625.1 acyl-CoA thioesterase II -
YPN_RS05095 1105726..1106247 + 522 WP_002208624.1 lipoprotein -
YPN_RS05100 1106383..1106772 - 390 WP_002208623.1 MGMT family protein -
YPN_RS05105 1107660..1107863 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
YPN_RS05110 1107912..1108280 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
YPN_RS05115 1108439..1108792 - 354 WP_002208619.1 hypothetical protein -
YPN_RS05120 1109666..1109809 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
YPN_RS05125 1109825..1110085 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T21586 WP_002208622.1 NC_008149:c1107863-1107660 [Yersinia pestis Nepal516]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T21586 NC_008149:c1107863-1107660 [Yersinia pestis Nepal516]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT21586 WP_002218472.1 NC_008149:c1108280-1107912 [Yersinia pestis Nepal516]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT21586 NC_008149:c1108280-1107912 [Yersinia pestis Nepal516]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References