Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870683..871340 Replicon chromosome
Accession NZ_CP083007
Organism Klebsiella pneumoniae strain 6711.43

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K9F29_RS04395 Protein ID WP_002916310.1
Coordinates 870930..871340 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K9F29_RS04390 Protein ID WP_002916312.1
Coordinates 870683..870949 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F29_RS04365 (K9F29_04360) 865839..867272 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K9F29_RS04370 (K9F29_04365) 867391..868119 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K9F29_RS04375 (K9F29_04370) 868169..868480 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
K9F29_RS04380 (K9F29_04375) 868644..869303 + 660 WP_002916317.1 hemolysin III family protein -
K9F29_RS04385 (K9F29_04380) 869454..870437 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K9F29_RS04390 (K9F29_04385) 870683..870949 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K9F29_RS04395 (K9F29_04390) 870930..871340 + 411 WP_002916310.1 protein YgfX Toxin
K9F29_RS04400 (K9F29_04395) 871347..871868 - 522 WP_002916308.1 flavodoxin FldB -
K9F29_RS04405 (K9F29_04400) 871969..872865 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K9F29_RS04410 (K9F29_04405) 872888..873601 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9F29_RS04415 (K9F29_04410) 873607..875340 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T215857 WP_002916310.1 NZ_CP083007:870930-871340 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215857 NZ_CP110978:c4238677-4238504 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215857 WP_002916312.1 NZ_CP083007:870683-870949 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215857 NZ_CP110978:c4239001-4238705 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References