Detailed information of TA system TA021585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 42822..43356
• Replicon: plasmid pCD
• Accession: NC_008122
• Organism: Yersinia pestis Antiqua

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q663N8
• Locus tag: YPA_RS22620
• Protein ID: WP_002213360.1
• Coordinates: 43057..43356 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9ZGW3
• Locus tag: YPA_RS22615
• Protein ID: WP_002224342.1
• Coordinates: 42822..43064 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPA_RS22605	39432..40598	+	1167	WP_002220902.1	plasmid-partitioning protein SopA	-
YPA_RS22610	40595..41560	+	966	WP_002213354.1	ParB/RepB/Spo0J family plasmid partition protein	-
YPA_RS25445	41720..41956	+	237	WP_154020274.1	hypothetical protein	-
YPA_RS25630	42105..42278	-	174	WP_002213357.1	hypothetical protein	-
YPA_RS24740	42364..42656	+	293	Protein_57	IS6 family transposase	-
YPA_RS22615	42822..43064	+	243	WP_002224342.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
YPA_RS22620	43057..43356	+	300	WP_002213360.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
YPA_RS22625	43496..44155	-	660	WP_002229754.1	type III secretion system effector GTPase activator YopE	-
YPA_RS22630	44349..44741	+	393	WP_002213403.1	type III secretion system chaperone SycE/YerA	-
YPA_RS22635	44804..45448	-	645	Protein_62	IS3 family transposase	-
YPA_RS22645	45551..46723	+	1173	WP_002220893.1	IS21 family transposase	-
YPA_RS22650	46723..47120	+	398	Protein_64	ATP-binding protein	-
YPA_RS22655	47496..47921	+	426	WP_002213267.1	type III secretion system chaperone SycH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	lcrQ/yscM / yscL / yscK / ylpB/yscJ / lcrO/yscI / yopR/yscH/lcrP / yscG / yscF / yscE / yscD / yscC / yscB / virG/yscW / yscU / yscT / yscS / yscR / yscQ / yscP / yscO / yscN / lcrE/yopN / tyeA / sycN / yscX / yscY / yscV/lcrD / lcrR / lcrG / lcrV / sycD/lcrH / yopB / yopD / yopM / sycT / yopT / yopK/yopQ / yopE / sycE/yerA / sycH / yadA / yadA / yopO/ypkA / yopJ/yopP / yopH	1..70299	70299

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• Antitoxin ParD (5-72)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11632.19 Da
• Isoelectric Point: 5.5114

>T21585 WP_002213360.1 NC_008122:43057-43356 [Yersinia pestis Antiqua]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE

Nucleotide

• Length: 300 bp

>T21585 NC_008122:43057-43356 [Yersinia pestis Antiqua]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8865.15 Da
• Isoelectric Point: 6.4781

>AT21585 WP_002224342.1 NC_008122:42822-43064 [Yersinia pestis Antiqua]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV

Nucleotide

• Length: 243 bp

>AT21585 NC_008122:42822-43064 [Yersinia pestis Antiqua]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Structures

Toxin

• AlphaFold DB: Q663N8

Antitoxin

• AlphaFold DB: A0A0E1NQY6