Detailed information of TA system TA215846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2825091..2826679
• Replicon: chromosome
• Accession: NZ_CP083000
• Organism: Klebsiella pneumoniae strain 6712.08

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K9F30_RS14040
• Protein ID: WP_004184027.1
• Coordinates: 2825091..2826413 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K9F30_RS14045
• Protein ID: WP_004176198.1
• Coordinates: 2826413..2826679 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9F30_RS14025 (2820147)	2820147..2822648	+	2502	WP_032418977.1	fimbria/pilus outer membrane usher protein	-
K9F30_RS14030 (2822636)	2822636..2823640	+	1005	WP_016946380.1	fimbrial protein	-
K9F30_RS14035 (2823782)	2823782..2825074	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
K9F30_RS14040 (2825091)	2825091..2826413	-	1323	WP_004184027.1	type II toxin-antitoxin system HipA family toxin	Toxin
K9F30_RS14045 (2826413)	2826413..2826679	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K9F30_RS14050 (2826945)	2826945..2827271	-	327	WP_004215084.1	hydroxyisourate hydrolase	-
K9F30_RS14055 (2827268)	2827268..2827768	-	501	WP_032418978.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
K9F30_RS14060 (2827746)	2827746..2829125	-	1380	WP_032418979.1	nucleobase:cation symporter-2 family protein	-
K9F30_RS14065 (2829471)	2829471..2830625	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
K9F30_RS14070 (2830606)	2830606..2831529	-	924	WP_032418980.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49139.47 Da
• Isoelectric Point: 7.5367

>T215846 WP_004184027.1 NZ_CP083000:c2826413-2825091 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T215846 NZ_CP110978:c2421667-2421491 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGTGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT215846 WP_004176198.1 NZ_CP083000:c2826679-2826413 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT215846 NZ_CP110978:c2421445-2421029 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA