Detailed information of TA system TA021584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 912673..913297
• Replicon: chromosome
• Accession: NC_008086
• Organism: Helicobacter pylori HPAG1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q1CSY2
• Locus tag: HPAG1_RS04410
• Protein ID: WP_011550059.1
• Coordinates: 912673..912939 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q1CSY1
• Locus tag: HPAG1_RS04415
• Protein ID: WP_001134064.1
• Coordinates: 912920..913297 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPAG1_RS04380	908125..909198	-	1074	WP_187145837.1	glycosyltransferase family 8 protein	-
HPAG1_RS04385	909309..910076	-	768	WP_000242349.1	ABC transporter ATP-binding protein	-
HPAG1_RS04390	910076..911056	-	981	WP_000921465.1	iron ABC transporter permease	-
HPAG1_RS04395	911049..911903	-	855	WP_000538083.1	SDR family oxidoreductase	-
HPAG1_RS04400	912043..912567	+	525	WP_001135623.1	acyl-CoA thioesterase	-
HPAG1_RS04410	912673..912939	-	267	WP_011550059.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPAG1_RS04415	912920..913297	-	378	WP_001134064.1	hypothetical protein	Antitoxin
HPAG1_RS04425	913627..915861	-	2235	WP_000716293.1	Hop family adhesin BabA	-
HPAG1_RS04440	916369..917003	+	635	Protein_852	hypothetical protein	-
HPAG1_RS04445	916954..918066	-	1113	WP_000109782.1	hydrogenase formation protein HypD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10372.32 Da
• Isoelectric Point: 9.6037

>T21584 WP_011550059.1 NC_008086:c912939-912673 [Helicobacter pylori HPAG1]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILTLRKKEPLDPQFKDHALKGKWKPFRECHIKPDILLVYLVKDDELILLR
LGSHSELF

Nucleotide

• Length: 267 bp

>T21584 NC_008086:c912939-912673 [Helicobacter pylori HPAG1]
GTGTTGAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAACCTTAAGAAAAAAAGAACCGCTAGACCCCCAATTCAAAGATCATGCTTTAAAGGGAAAGTGGA
AGCCTTTTAGGGAATGCCACATTAAGCCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGA
CTAGGCAGTCATAGCGAATTGTTTTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14748.78 Da
• Isoelectric Point: 9.4142

>AT21584 WP_001134064.1 NC_008086:c913297-912920 [Helicobacter pylori HPAG1]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNIQTQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQS

Nucleotide

• Length: 378 bp

>AT21584 NC_008086:c913297-912920 [Helicobacter pylori HPAG1]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCACTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCTTTGGGTGTTGAAACTCAATCTTAA

Structures

Toxin

• AlphaFold DB: Q1CSY2

Antitoxin

• AlphaFold DB: Q1CSY1