Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4770903..4771419 Replicon chromosome
Accession NZ_CP082995
Organism Klebsiella pneumoniae strain 6911.28

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K9F31_RS23595 Protein ID WP_002886902.1
Coordinates 4770903..4771187 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K9F31_RS23600 Protein ID WP_002886901.1
Coordinates 4771177..4771419 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F31_RS23570 (K9F31_23530) 4766387..4766650 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
K9F31_RS23575 (K9F31_23535) 4766780..4766953 + 174 WP_002886906.1 hypothetical protein -
K9F31_RS23580 (K9F31_23540) 4766956..4767699 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K9F31_RS23585 (K9F31_23545) 4768056..4770194 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K9F31_RS23590 (K9F31_23550) 4770435..4770899 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K9F31_RS23595 (K9F31_23555) 4770903..4771187 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9F31_RS23600 (K9F31_23560) 4771177..4771419 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K9F31_RS23605 (K9F31_23565) 4771497..4773407 - 1911 WP_004152270.1 PRD domain-containing protein -
K9F31_RS23610 (K9F31_23570) 4773430..4774584 - 1155 WP_002886900.1 lactonase family protein -
K9F31_RS23615 (K9F31_23575) 4774650..4775390 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T215831 WP_002886902.1 NZ_CP082995:c4771187-4770903 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T215831 NZ_CP110967:c5362567-5362184 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT215831 WP_002886901.1 NZ_CP082995:c4771419-4771177 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT215831 NZ_CP110967:c5362809-5362567 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References