Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 895410..896067 Replicon chromosome
Accession NZ_CP082995
Organism Klebsiella pneumoniae strain 6911.28

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K9F31_RS04515 Protein ID WP_002916310.1
Coordinates 895657..896067 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K9F31_RS04510 Protein ID WP_002916312.1
Coordinates 895410..895676 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F31_RS04485 (K9F31_04480) 890566..891999 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K9F31_RS04490 (K9F31_04485) 892118..892846 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K9F31_RS04495 (K9F31_04490) 892896..893207 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
K9F31_RS04500 (K9F31_04495) 893371..894030 + 660 WP_002916317.1 hemolysin III family protein -
K9F31_RS04505 (K9F31_04500) 894181..895164 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K9F31_RS04510 (K9F31_04505) 895410..895676 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K9F31_RS04515 (K9F31_04510) 895657..896067 + 411 WP_002916310.1 protein YgfX Toxin
K9F31_RS04520 (K9F31_04515) 896074..896595 - 522 WP_002916308.1 flavodoxin FldB -
K9F31_RS04525 (K9F31_04520) 896696..897592 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K9F31_RS04530 (K9F31_04525) 897615..898328 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9F31_RS04535 (K9F31_04530) 898334..900067 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T215819 WP_002916310.1 NZ_CP082995:895657-896067 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215819 NZ_CP110962:c5251934-5251551 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215819 WP_002916312.1 NZ_CP082995:895410-895676 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215819 NZ_CP110962:c5252176-5251934 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References