Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 734224..734870 Replicon chromosome
Accession NC_008027
Organism Pseudomonas entomophila L48

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PSEEN_RS03305 Protein ID WP_044487636.1
Coordinates 734224..734406 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q1IFB6
Locus tag PSEEN_RS03310 Protein ID WP_011532070.1
Coordinates 734463..734870 (+) Length 136 a.a.

Genomic Context

PSEEN_RS03305PSEEN_RS03310PSEEN_RS03320PSEEN_RS03325PSEEN_RS03330PSEEN_RS03280PSEEN_RS03285PSEEN_RS03290PSEEN_RS03295PSEEN_RS03300PSEEN_RS03315
Location: 734224..734406 (183 bp)
Type: Toxin
Protein ID: WP_044487636.1
Location: 734463..734870 (408 bp)
Type: Antitoxin
Protein ID: WP_011532070.1
Location: 735427..736014 (588 bp)
Type: Others
Protein ID: WP_011532072.1
Location: 736203..737099 (897 bp)
Type: Others
Protein ID: WP_011532073.1
Location: 737219..738886 (1668 bp)
Type: Others
Protein ID: WP_011532074.1
Location: 729234..729857 (624 bp)
Type: Others
Protein ID: WP_011532064.1
Location: 729868..730287 (420 bp)
Type: Others
Protein ID: WP_011532065.1
Location: 730284..731618 (1335 bp)
Type: Others
Protein ID: WP_011532066.1
Location: 731618..733372 (1755 bp)
Type: Others
Protein ID: WP_011532067.1
Location: 733404..734009 (606 bp)
Type: Others
Protein ID: WP_011532068.1
Location: 734911..735225 (315 bp)
Type: Others
Protein ID: WP_011532071.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PSEEN_RS03280729234..729857-624WP_011532064.11-acyl-sn-glycerol-3-phosphate acyltransferase-
PSEEN_RS03285729868..730287-420WP_011532065.1hypothetical protein-
PSEEN_RS03290730284..731618-1335WP_011532066.1phosphatase PAP2/dual specificity phosphatase family protein-
PSEEN_RS03295731618..733372-1755WP_011532067.1bifunctional alpha/beta hydrolase/class I SAM-dependent methyltransferase-
PSEEN_RS03300733404..734009-606WP_011532068.1CDP-alcohol phosphatidyltransferase family protein-
PSEEN_RS03305734224..734406+183WP_044487636.1type II toxin-antitoxin system HicA family toxinToxin
PSEEN_RS03310734463..734870+408WP_011532070.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
PSEEN_RS03315734911..735225-315WP_011532071.1antibiotic biosynthesis monooxygenase-
PSEEN_RS03320735427..736014+588WP_011532072.1NAD(P)H-dependent oxidoreductase-
PSEEN_RS03325736203..737099+897WP_011532073.1LysR family transcriptional regulator-
PSEEN_RS03330737219..738886+1668WP_011532074.1gamma-glutamyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6898.92 Da        Isoelectric Point: 10.9595

>T21579 WP_044487636.1 NC_008027:734224-734406 [Pseudomonas entomophila L48]
MRSRDVIQLIEADGWYEVEVKGSHHQFRHPFKRGRVTVPHPKSDLPRGTAHSILKQAGLK

Download         Length: 183 bp

>T21579 NC_008027:734224-734406 [Pseudomonas entomophila L48]
ATGCGCAGCAGGGACGTGATCCAGCTCATCGAGGCCGATGGCTGGTACGAGGTTGAAGTGAAGGGCAGCCATCATCAGTT
CAGGCACCCGTTCAAGCGAGGGCGGGTCACGGTGCCACATCCCAAGAGCGATCTCCCCAGGGGCACCGCCCACAGCATCC
TCAAGCAGGCGGGCCTGAAGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14704.54 Da        Isoelectric Point: 4.6025

>AT21579 WP_011532070.1 NC_008027:734463-734870 [Pseudomonas entomophila L48]
MKFPVVLHKDEGSDYGVIVPDVPGCFSAGFSVSQALDNVQEALALHFEGLVADGEALPQAQEVDVHVANPDYADGVWAVV
EFDVTPYLGKAVRFNATLPENLLQRIDERVKRDHRYASRSGFLASAALRELAVAH

Download         Length: 408 bp

>AT21579 NC_008027:734463-734870 [Pseudomonas entomophila L48]
ATGAAATTTCCAGTTGTGCTGCACAAGGACGAGGGCTCGGACTACGGCGTGATCGTGCCCGATGTGCCAGGCTGCTTCTC
CGCAGGTTTCAGCGTTTCCCAGGCGCTGGACAACGTCCAGGAGGCCCTGGCGCTGCATTTCGAAGGGCTGGTGGCCGATG
GCGAGGCGCTGCCCCAGGCCCAGGAAGTGGACGTGCATGTGGCTAACCCCGACTACGCCGACGGCGTCTGGGCGGTGGTG
GAGTTCGACGTCACCCCGTACCTGGGCAAGGCGGTACGTTTCAACGCGACGCTGCCGGAGAACCTGCTGCAGCGGATCGA
CGAGAGGGTGAAGCGTGACCATCGCTACGCCTCGCGCTCGGGTTTTCTCGCTTCGGCGGCGCTGCGCGAGCTGGCCGTGG
CGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ1IFB6

References