Detailed information of TA system TA021579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 734224..734870
• Replicon: chromosome
• Accession: NC_008027
• Organism: Pseudomonas entomophila L48

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PSEEN_RS03305
• Protein ID: WP_044487636.1
• Coordinates: 734224..734406 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q1IFB6
• Locus tag: PSEEN_RS03310
• Protein ID: WP_011532070.1
• Coordinates: 734463..734870 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PSEEN_RS03280	729234..729857	-	624	WP_011532064.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
PSEEN_RS03285	729868..730287	-	420	WP_011532065.1	hypothetical protein	-
PSEEN_RS03290	730284..731618	-	1335	WP_011532066.1	phosphatase PAP2/dual specificity phosphatase family protein	-
PSEEN_RS03295	731618..733372	-	1755	WP_011532067.1	bifunctional alpha/beta hydrolase/class I SAM-dependent methyltransferase	-
PSEEN_RS03300	733404..734009	-	606	WP_011532068.1	CDP-alcohol phosphatidyltransferase family protein	-
PSEEN_RS03305	734224..734406	+	183	WP_044487636.1	type II toxin-antitoxin system HicA family toxin	Toxin
PSEEN_RS03310	734463..734870	+	408	WP_011532070.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PSEEN_RS03315	734911..735225	-	315	WP_011532071.1	antibiotic biosynthesis monooxygenase	-
PSEEN_RS03320	735427..736014	+	588	WP_011532072.1	NAD(P)H-dependent oxidoreductase	-
PSEEN_RS03325	736203..737099	+	897	WP_011532073.1	LysR family transcriptional regulator	-
PSEEN_RS03330	737219..738886	+	1668	WP_011532074.1	gamma-glutamyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6898.92 Da
• Isoelectric Point: 10.9595

>T21579 WP_044487636.1 NC_008027:734224-734406 [Pseudomonas entomophila L48]
MRSRDVIQLIEADGWYEVEVKGSHHQFRHPFKRGRVTVPHPKSDLPRGTAHSILKQAGLK

Nucleotide

• Length: 183 bp

>T21579 NC_008027:734224-734406 [Pseudomonas entomophila L48]
ATGCGCAGCAGGGACGTGATCCAGCTCATCGAGGCCGATGGCTGGTACGAGGTTGAAGTGAAGGGCAGCCATCATCAGTT
CAGGCACCCGTTCAAGCGAGGGCGGGTCACGGTGCCACATCCCAAGAGCGATCTCCCCAGGGGCACCGCCCACAGCATCC
TCAAGCAGGCGGGCCTGAAGTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14704.54 Da
• Isoelectric Point: 4.6025

>AT21579 WP_011532070.1 NC_008027:734463-734870 [Pseudomonas entomophila L48]
MKFPVVLHKDEGSDYGVIVPDVPGCFSAGFSVSQALDNVQEALALHFEGLVADGEALPQAQEVDVHVANPDYADGVWAVV
EFDVTPYLGKAVRFNATLPENLLQRIDERVKRDHRYASRSGFLASAALRELAVAH

Nucleotide

• Length: 408 bp

>AT21579 NC_008027:734463-734870 [Pseudomonas entomophila L48]
ATGAAATTTCCAGTTGTGCTGCACAAGGACGAGGGCTCGGACTACGGCGTGATCGTGCCCGATGTGCCAGGCTGCTTCTC
CGCAGGTTTCAGCGTTTCCCAGGCGCTGGACAACGTCCAGGAGGCCCTGGCGCTGCATTTCGAAGGGCTGGTGGCCGATG
GCGAGGCGCTGCCCCAGGCCCAGGAAGTGGACGTGCATGTGGCTAACCCCGACTACGCCGACGGCGTCTGGGCGGTGGTG
GAGTTCGACGTCACCCCGTACCTGGGCAAGGCGGTACGTTTCAACGCGACGCTGCCGGAGAACCTGCTGCAGCGGATCGA
CGAGAGGGTGAAGCGTGACCATCGCTACGCCTCGCGCTCGGGTTTTCTCGCTTCGGCGGCGCTGCGCGAGCTGGCCGTGG
CGCATTGA

Structures

Antitoxin

• AlphaFold DB: Q1IFB6