Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 791277..791934 Replicon chromosome
Accession NZ_CP082985
Organism Klebsiella pneumoniae strain 7011.62

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K9F33_RS03935 Protein ID WP_002916310.1
Coordinates 791524..791934 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K9F33_RS03930 Protein ID WP_002916312.1
Coordinates 791277..791543 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F33_RS03905 (786485) 786485..787918 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
K9F33_RS03910 (788037) 788037..788765 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K9F33_RS03915 (788815) 788815..789126 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K9F33_RS03920 (789290) 789290..789949 + 660 WP_002916317.1 hemolysin III family protein -
K9F33_RS03925 (790048) 790048..791031 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K9F33_RS03930 (791277) 791277..791543 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K9F33_RS03935 (791524) 791524..791934 + 411 WP_002916310.1 protein YgfX Toxin
K9F33_RS03940 (791941) 791941..792462 - 522 WP_002916308.1 flavodoxin FldB -
K9F33_RS03945 (792563) 792563..793459 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K9F33_RS03950 (793482) 793482..794195 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9F33_RS03955 (794201) 794201..795934 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T215776 WP_002916310.1 NZ_CP082985:791524-791934 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215776 NZ_CP110947:4045949-4046167 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215776 WP_002916312.1 NZ_CP082985:791277-791543 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215776 NZ_CP110947:4045548-4045922 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References