Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RelB(antitoxin) |
Location | 1690651..1691263 | Replicon | chromosome |
Accession | NC_008024 | ||
Organism | Streptococcus pyogenes MGAS10750 |
Toxin (Protein)
Gene name | parE | Uniprot ID | Q1JJZ2 |
Locus tag | MGAS10750_RS08510 | Protein ID | WP_002988077.1 |
Coordinates | 1690928..1691263 (+) | Length | 112 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | Q5X9X9 |
Locus tag | MGAS10750_RS08505 | Protein ID | WP_002988079.1 |
Coordinates | 1690651..1690938 (+) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MGAS10750_RS08480 | 1685840..1686823 | - | 984 | WP_011529001.1 | tagatose-bisphosphate aldolase | - |
MGAS10750_RS08485 | 1686827..1687756 | - | 930 | WP_011529002.1 | tagatose-6-phosphate kinase | - |
MGAS10750_RS08490 | 1687804..1688319 | - | 516 | WP_011529003.1 | galactose-6-phosphate isomerase subunit LacB | - |
MGAS10750_RS08495 | 1688354..1688782 | - | 429 | WP_011529004.1 | galactose-6-phosphate isomerase subunit LacA | - |
MGAS10750_RS08500 | 1689228..1690001 | + | 774 | WP_011529005.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
MGAS10750_RS08505 | 1690651..1690938 | + | 288 | WP_002988079.1 | DNA-damage-inducible protein J | Antitoxin |
MGAS10750_RS08510 | 1690928..1691263 | + | 336 | WP_002988077.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
MGAS10750_RS10125 | 1691402..1691578 | + | 177 | Protein_1618 | tyrosine-type recombinase/integrase | - |
MGAS10750_RS08515 | 1691709..1692101 | - | 393 | WP_002982716.1 | 30S ribosomal protein S9 | - |
MGAS10750_RS08520 | 1692122..1692568 | - | 447 | WP_002982710.1 | 50S ribosomal protein L13 | - |
MGAS10750_RS08525 | 1692786..1692992 | - | 207 | WP_011529007.1 | helix-turn-helix transcriptional regulator | - |
MGAS10750_RS08530 | 1692989..1693687 | - | 699 | WP_021299047.1 | hypothetical protein | - |
MGAS10750_RS08535 | 1693823..1694683 | - | 861 | WP_011529009.1 | DegV family protein | - |
MGAS10750_RS08540 | 1694780..1695298 | - | 519 | WP_011055010.1 | NYN domain-containing protein | - |
MGAS10750_RS08545 | 1695302..1696048 | - | 747 | WP_010922667.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 13117.83 Da Isoelectric Point: 5.2144
>T21577 WP_002988077.1 NC_008024:1690928-1691263 [Streptococcus pyogenes MGAS10750]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK
Download Length: 336 bp
>T21577 NC_008024:1690928-1691263 [Streptococcus pyogenes MGAS10750]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10934.56 Da Isoelectric Point: 5.2318
>AT21577 WP_002988079.1 NC_008024:1690651-1690938 [Streptococcus pyogenes MGAS10750]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL
Download Length: 288 bp
>AT21577 NC_008024:1690651-1690938 [Streptococcus pyogenes MGAS10750]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A660A236 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4U7GX94 |