Detailed information of TA system TA215767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2849571..2851159
• Replicon: chromosome
• Accession: NZ_CP082978
• Organism: Klebsiella pneumoniae strain BD-13

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K9F21_RS14305
• Protein ID: WP_004184027.1
• Coordinates: 2849571..2850893 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K9F21_RS14310
• Protein ID: WP_004176198.1
• Coordinates: 2850893..2851159 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9F21_RS14290 (2844627)	2844627..2847128	+	2502	WP_032418977.1	fimbria/pilus outer membrane usher protein	-
K9F21_RS14295 (2847116)	2847116..2848120	+	1005	WP_016946380.1	fimbrial protein	-
K9F21_RS14300 (2848262)	2848262..2849554	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
K9F21_RS14305 (2849571)	2849571..2850893	-	1323	WP_004184027.1	type II toxin-antitoxin system HipA family toxin	Toxin
K9F21_RS14310 (2850893)	2850893..2851159	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K9F21_RS14315 (2851425)	2851425..2851751	-	327	WP_004215084.1	hydroxyisourate hydrolase	-
K9F21_RS14320 (2851748)	2851748..2852248	-	501	WP_032418978.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
K9F21_RS14325 (2852226)	2852226..2853605	-	1380	WP_032418979.1	nucleobase:cation symporter-2 family protein	-
K9F21_RS14330 (2853951)	2853951..2855105	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
K9F21_RS14335 (2855086)	2855086..2856009	-	924	WP_032418980.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49139.47 Da
• Isoelectric Point: 7.5367

>T215767 WP_004184027.1 NZ_CP082978:c2850893-2849571 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T215767 NZ_CP110941:c5264299-5263916 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT215767 WP_004176198.1 NZ_CP082978:c2851159-2850893 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT215767 NZ_CP110941:c5264541-5264299 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA