Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1876669..1877155 Replicon chromosome
Accession NC_008022
Organism Streptococcus pyogenes MGAS10270

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag MGAS10270_RS09380 Protein ID WP_014407961.1
Coordinates 1876669..1876938 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag MGAS10270_RS09385 Protein ID WP_014407962.1
Coordinates 1876928..1877155 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGAS10270_RS09365 1872157..1873236 + 1080 WP_020905593.1 DUF4097 domain-containing protein -
MGAS10270_RS09370 1873354..1875627 - 2274 WP_021775373.1 YhgE/Pip domain-containing protein -
MGAS10270_RS09375 1875762..1876295 + 534 WP_002982093.1 TetR/AcrR family transcriptional regulator -
MGAS10270_RS09380 1876669..1876938 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MGAS10270_RS09385 1876928..1877155 - 228 WP_014407962.1 hypothetical protein Antitoxin
MGAS10270_RS09390 1877308..1877679 - 372 WP_011285302.1 DUF1492 domain-containing protein -
MGAS10270_RS09395 1877669..1878016 - 348 WP_011285303.1 DUF1492 domain-containing protein -
MGAS10270_RS09400 1878297..1878542 - 246 WP_011285304.1 hypothetical protein -
MGAS10270_RS09405 1878517..1878792 - 276 WP_014407964.1 hypothetical protein -
MGAS10270_RS09410 1878782..1879120 - 339 WP_030126557.1 replication protein -
MGAS10270_RS09415 1879162..1879428 - 267 WP_011285307.1 hypothetical protein -
MGAS10270_RS09420 1879425..1880213 - 789 WP_011285308.1 hypothetical protein -
MGAS10270_RS10415 1880304..1880462 - 159 WP_011285309.1 hypothetical protein -
MGAS10270_RS09430 1880476..1880721 - 246 WP_011285310.1 hypothetical protein -
MGAS10270_RS09435 1880717..1881043 - 327 Protein_1798 hypothetical protein -
MGAS10270_RS10420 1881045..1881218 - 174 WP_011285312.1 hypothetical protein -
MGAS10270_RS10160 1881224..1881397 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T21576 WP_014407961.1 NC_008022:c1876938-1876669 [Streptococcus pyogenes MGAS10270]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T21576 NC_008022:c1876938-1876669 [Streptococcus pyogenes MGAS10270]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT21576 WP_014407962.1 NC_008022:c1877155-1876928 [Streptococcus pyogenes MGAS10270]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT21576 NC_008022:c1877155-1876928 [Streptococcus pyogenes MGAS10270]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References