215753

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 55796..56582 Replicon plasmid p1-BD-14-NDM1
Accession NZ_CP082976
Organism Klebsiella pneumoniae strain BD-14

Toxin (Protein)


Gene name yeeV Uniprot ID R8WN26
Locus tag K9F22_RS26270 Protein ID WP_016154457.1
Coordinates 55796..56173 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A242VSK1
Locus tag K9F22_RS26275 Protein ID WP_009652436.1
Coordinates 56223..56582 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F22_RS26235 (K9F22_26175) 51054..52022 - 969 WP_074449071.1 IS5 family transposase -
K9F22_RS26240 (K9F22_26180) 52054..52122 - 69 Protein_64 tellurium resistance protein TerY -
K9F22_RS26245 (K9F22_26185) 52442..52915 - 474 WP_009652494.1 ribbon-helix-helix protein, CopG family -
K9F22_RS26250 (K9F22_26190) 52918..53949 - 1032 WP_223175620.1 hypothetical protein -
K9F22_RS26255 (K9F22_26195) 54149..54994 - 846 Protein_67 DUF4942 domain-containing protein -
K9F22_RS26260 (K9F22_26200) 55075..55278 - 204 WP_009652505.1 DUF957 domain-containing protein -
K9F22_RS26265 (K9F22_26205) 55308..55799 - 492 WP_009652438.1 DUF5983 family protein -
K9F22_RS26270 (K9F22_26210) 55796..56173 - 378 WP_016154457.1 TA system toxin CbtA family protein Toxin
K9F22_RS26275 (K9F22_26215) 56223..56582 - 360 WP_009652436.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K9F22_RS26280 (K9F22_26220) 56606..56827 - 222 WP_009652392.1 DUF987 domain-containing protein -
K9F22_RS26285 (K9F22_26225) 56841..57323 - 483 WP_052238324.1 DNA repair protein RadC -
K9F22_RS26290 (K9F22_26230) 57335..57553 - 219 WP_009652503.1 hypothetical protein -
K9F22_RS26295 (K9F22_26235) 57564..58037 - 474 WP_009652453.1 antirestriction protein -
K9F22_RS26300 (K9F22_26240) 58054..58308 - 255 WP_009652519.1 hypothetical protein -
K9F22_RS26305 (K9F22_26245) 58308..59126 - 819 WP_009652424.1 DUF932 domain-containing protein -
K9F22_RS26310 (K9F22_26250) 59230..59463 - 234 WP_009652474.1 DUF905 domain-containing protein -
K9F22_RS26315 (K9F22_26255) 59519..59740 - 222 WP_009652443.1 hypothetical protein -
K9F22_RS26320 (K9F22_26260) 59823..60335 - 513 WP_009652395.1 DUF4234 domain-containing protein -
K9F22_RS26325 (K9F22_26265) 60384..60854 - 471 WP_009652431.1 hypothetical protein -
K9F22_RS26330 (K9F22_26270) 60901..61212 - 312 WP_009652410.1 hypothetical protein -
K9F22_RS26335 (K9F22_26275) 61225..61491 - 267 WP_009652486.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / aac(6')-Ib-cr / blaOXA-1 / blaCTX-M-15 / qnrS1 / aph(3')-VI / blaNDM-1 / catA1 - 1..342741 342741
- flank IS/Tn - - 51054..52022 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14168.19 Da        Isoelectric Point: 9.5224

>T215753 WP_016154457.1 NZ_CP082976:c56173-55796 [Klebsiella pneumoniae]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Download         Length: 378 bp

>T215753 NZ_CP110936:c4964273-4963905 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13286.19 Da        Isoelectric Point: 6.4780

>AT215753 WP_009652436.1 NZ_CP082976:c56582-56223 [Klebsiella pneumoniae]
MSNTIPPVNHDIAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELN
PRHQHCVTLYAKGLICEADSLGSHGYVYLAIYPTPATTE

Download         Length: 360 bp

>AT215753 NZ_CP110936:c4964491-4964270 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN26

Antitoxin

Source ID Structure
AlphaFold DB A0A242VSK1

References