Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4758239..4758755 Replicon chromosome
Accession NZ_CP082975
Organism Klebsiella pneumoniae strain BD-14

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag K9F22_RS23300 Protein ID WP_009309309.1
Coordinates 4758239..4758523 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K9F22_RS23305 Protein ID WP_002886901.1
Coordinates 4758513..4758755 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F22_RS23275 (4753722) 4753722..4753985 - 264 WP_025987940.1 PTS sugar transporter subunit IIB -
K9F22_RS23280 (4754115) 4754115..4754288 + 174 WP_019725541.1 hypothetical protein -
K9F22_RS23285 (4754291) 4754291..4755034 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K9F22_RS23290 (4755391) 4755391..4757529 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K9F22_RS23295 (4757771) 4757771..4758235 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K9F22_RS23300 (4758239) 4758239..4758523 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9F22_RS23305 (4758513) 4758513..4758755 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K9F22_RS23310 (4758833) 4758833..4760743 - 1911 WP_004152270.1 PRD domain-containing protein -
K9F22_RS23315 (4760766) 4760766..4761920 - 1155 WP_002886900.1 lactonase family protein -
K9F22_RS23320 (4761987) 4761987..4762727 - 741 WP_032417761.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T215750 WP_009309309.1 NZ_CP082975:c4758523-4758239 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T215750 NZ_CP110936:c4417753-4417343 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT215750 WP_002886901.1 NZ_CP082975:c4758755-4758513 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT215750 NZ_CP110936:c4418000-4417734 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References