Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1659702..1660314 Replicon chromosome
Accession NC_008022
Organism Streptococcus pyogenes MGAS10270

Toxin (Protein)


Gene name parE Uniprot ID Q1JEY4
Locus tag MGAS10270_RS08375 Protein ID WP_020905490.1
Coordinates 1659979..1660314 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag MGAS10270_RS08370 Protein ID WP_002988079.1
Coordinates 1659702..1659989 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGAS10270_RS08345 1654882..1655865 - 984 WP_020905487.1 tagatose-bisphosphate aldolase -
MGAS10270_RS08350 1655869..1656798 - 930 WP_020905488.1 tagatose-6-phosphate kinase -
MGAS10270_RS08355 1656844..1657359 - 516 WP_020905489.1 galactose-6-phosphate isomerase subunit LacB -
MGAS10270_RS08360 1657394..1657822 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
MGAS10270_RS08365 1658268..1659041 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
MGAS10270_RS08370 1659702..1659989 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
MGAS10270_RS08375 1659979..1660314 + 336 WP_020905490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MGAS10270_RS10390 1660466..1660936 + 471 Protein_1586 tyrosine-type recombinase/integrase family protein -
MGAS10270_RS10395 1661298..1661399 + 102 WP_180372495.1 hypothetical protein -
MGAS10270_RS08380 1661567..1661959 - 393 WP_002982716.1 30S ribosomal protein S9 -
MGAS10270_RS08385 1661980..1662426 - 447 WP_002982710.1 50S ribosomal protein L13 -
MGAS10270_RS08390 1662644..1662850 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
MGAS10270_RS08395 1662847..1663545 - 699 WP_021775254.1 hypothetical protein -
MGAS10270_RS08400 1663681..1664541 - 861 WP_020905495.1 DegV family protein -
MGAS10270_RS08405 1664638..1665156 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13147.98 Da        Isoelectric Point: 4.9405

>T21575 WP_020905490.1 NC_008022:1659979-1660314 [Streptococcus pyogenes MGAS10270]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIILYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T21575 NC_008022:1659979-1660314 [Streptococcus pyogenes MGAS10270]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCTTTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT21575 WP_002988079.1 NC_008022:1659702-1659989 [Streptococcus pyogenes MGAS10270]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT21575 NC_008022:1659702-1659989 [Streptococcus pyogenes MGAS10270]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1JEY4

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References