Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1597558..1598170 Replicon chromosome
Accession NC_008021
Organism Streptococcus pyogenes MGAS9429

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag MGAS9429_RS07960 Protein ID WP_002988077.1
Coordinates 1597835..1598170 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag MGAS9429_RS07955 Protein ID WP_002988079.1
Coordinates 1597558..1597845 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGAS9429_RS07930 1592749..1593732 - 984 WP_002988088.1 tagatose-bisphosphate aldolase -
MGAS9429_RS07935 1593736..1594665 - 930 WP_002988085.1 tagatose-6-phosphate kinase -
MGAS9429_RS07940 1594711..1595226 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
MGAS9429_RS07945 1595261..1595689 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
MGAS9429_RS07950 1596135..1596908 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
MGAS9429_RS07955 1597558..1597845 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
MGAS9429_RS07960 1597835..1598170 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MGAS9429_RS09790 1598322..1598792 + 471 WP_002988074.1 integrase -
MGAS9429_RS09795 1598755..1599117 + 363 WP_180373113.1 tyrosine-type recombinase/integrase -
MGAS9429_RS09800 1599153..1599302 + 150 WP_002982720.1 hypothetical protein -
MGAS9429_RS07970 1599422..1599814 - 393 WP_002982716.1 30S ribosomal protein S9 -
MGAS9429_RS07975 1599835..1600281 - 447 WP_002982710.1 50S ribosomal protein L13 -
MGAS9429_RS07980 1600499..1600704 - 206 Protein_1522 helix-turn-helix transcriptional regulator -
MGAS9429_RS07985 1600701..1601207 - 507 WP_002988070.1 hypothetical protein -
MGAS9429_RS07990 1601343..1602203 - 861 WP_002982687.1 DegV family protein -
MGAS9429_RS07995 1602300..1602818 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T21574 WP_002988077.1 NC_008021:1597835-1598170 [Streptococcus pyogenes MGAS9429]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T21574 NC_008021:1597835-1598170 [Streptococcus pyogenes MGAS9429]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT21574 WP_002988079.1 NC_008021:1597558-1597845 [Streptococcus pyogenes MGAS9429]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT21574 NC_008021:1597558-1597845 [Streptococcus pyogenes MGAS9429]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References