Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5382157..5382782 Replicon chromosome
Accession NZ_CP082967
Organism Klebsiella pneumoniae strain BD-41

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag K9F23_RS26455 Protein ID WP_002882817.1
Coordinates 5382157..5382540 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag K9F23_RS26460 Protein ID WP_004150355.1
Coordinates 5382540..5382782 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F23_RS26440 (5379523) 5379523..5380425 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
K9F23_RS26445 (5380422) 5380422..5381057 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
K9F23_RS26450 (5381054) 5381054..5381983 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
K9F23_RS26455 (5382157) 5382157..5382540 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
K9F23_RS26460 (5382540) 5382540..5382782 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
K9F23_RS26465 (5382987) 5382987..5383904 + 918 WP_032418237.1 alpha/beta hydrolase -
K9F23_RS26470 (5383918) 5383918..5384859 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
K9F23_RS26475 (5384904) 5384904..5385341 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
K9F23_RS26480 (5385338) 5385338..5386198 - 861 WP_004146232.1 virulence factor BrkB family protein -
K9F23_RS26485 (5386192) 5386192..5386791 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T215733 WP_002882817.1 NZ_CP082967:c5382540-5382157 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T215733 NZ_CP110934:c804670-804272 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT215733 WP_004150355.1 NZ_CP082967:c5382782-5382540 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT215733 NZ_CP110934:c804897-804670 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References