Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2795525..2797113 | Replicon | chromosome |
Accession | NZ_CP082967 | ||
Organism | Klebsiella pneumoniae strain BD-41 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | K9F23_RS13940 | Protein ID | WP_004184027.1 |
Coordinates | 2795525..2796847 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | K9F23_RS13945 | Protein ID | WP_004176198.1 |
Coordinates | 2796847..2797113 (-) | Length | 89 a.a. |
Genomic Context
Location: 2790581..2793082 (2502 bp)
Type: Others
Protein ID: WP_032418977.1
Type: Others
Protein ID: WP_032418977.1
Location: 2793070..2794074 (1005 bp)
Type: Others
Protein ID: WP_016946380.1
Type: Others
Protein ID: WP_016946380.1
Location: 2794216..2795508 (1293 bp)
Type: Others
Protein ID: WP_002904794.1
Type: Others
Protein ID: WP_002904794.1
Location: 2799905..2801059 (1155 bp)
Type: Others
Protein ID: WP_002904783.1
Type: Others
Protein ID: WP_002904783.1
Location: 2795525..2796847 (1323 bp)
Type: Toxin
Protein ID: WP_004184027.1
Type: Toxin
Protein ID: WP_004184027.1
Location: 2796847..2797113 (267 bp)
Type: Antitoxin
Protein ID: WP_004176198.1
Type: Antitoxin
Protein ID: WP_004176198.1
Location: 2797379..2797705 (327 bp)
Type: Others
Protein ID: WP_004215084.1
Type: Others
Protein ID: WP_004215084.1
Location: 2797702..2798202 (501 bp)
Type: Others
Protein ID: WP_032418978.1
Type: Others
Protein ID: WP_032418978.1
Location: 2798180..2799559 (1380 bp)
Type: Others
Protein ID: WP_032418979.1
Type: Others
Protein ID: WP_032418979.1
Location: 2801040..2801963 (924 bp)
Type: Others
Protein ID: WP_032418980.1
Type: Others
Protein ID: WP_032418980.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K9F23_RS13925 (2790581) | 2790581..2793082 | + | 2502 | WP_032418977.1 | fimbria/pilus outer membrane usher protein | - |
K9F23_RS13930 (2793070) | 2793070..2794074 | + | 1005 | WP_016946380.1 | fimbrial protein | - |
K9F23_RS13935 (2794216) | 2794216..2795508 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
K9F23_RS13940 (2795525) | 2795525..2796847 | - | 1323 | WP_004184027.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
K9F23_RS13945 (2796847) | 2796847..2797113 | - | 267 | WP_004176198.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
K9F23_RS13950 (2797379) | 2797379..2797705 | - | 327 | WP_004215084.1 | hydroxyisourate hydrolase | - |
K9F23_RS13955 (2797702) | 2797702..2798202 | - | 501 | WP_032418978.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
K9F23_RS13960 (2798180) | 2798180..2799559 | - | 1380 | WP_032418979.1 | nucleobase:cation symporter-2 family protein | - |
K9F23_RS13965 (2799905) | 2799905..2801059 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
K9F23_RS13970 (2801040) | 2801040..2801963 | - | 924 | WP_032418980.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49139.47 Da Isoelectric Point: 7.5367
>T215728 WP_004184027.1 NZ_CP082967:c2796847-2795525 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T215728 NZ_CP110933:14971-15369 [Salmonella enterica]
ATGCTGAAGTTTATGCTGGATACTAACATCTGCATTTTCACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCGGTCACCCTGATGGAGCTGATTTACGGTGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA
ATGCTGAAGTTTATGCTGGATACTAACATCTGCATTTTCACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCGGTCACCCTGATGGAGCTGATTTACGGTGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9936.36 Da Isoelectric Point: 8.5912
>AT215728 WP_004176198.1 NZ_CP082967:c2797113-2796847 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT215728 NZ_CP110933:14744-14971 [Salmonella enterica]
ATGGAAACCAGCGTATTTCTCAGTAACCGAAGTCAGGCGGTCAGACTGCCAAAAGCAGTGGCATTGCCGGAACATGTAAA
ACGTGTGGAAGTTATCGCTGTCGGGCGAACCCGGATCATCACGCCGGCCGGAGAATCGTGGGATGAATGGTTCGACGGGA
ACAACGTCAGCGCCGATTTTATGGATAACCGGGAACAACCCTCTGTGCAGGAACGGGAATCATTCTGA
ATGGAAACCAGCGTATTTCTCAGTAACCGAAGTCAGGCGGTCAGACTGCCAAAAGCAGTGGCATTGCCGGAACATGTAAA
ACGTGTGGAAGTTATCGCTGTCGGGCGAACCCGGATCATCACGCCGGCCGGAGAATCGTGGGATGAATGGTTCGACGGGA
ACAACGTCAGCGCCGATTTTATGGATAACCGGGAACAACCCTCTGTGCAGGAACGGGAATCATTCTGA