Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2795525..2797113 Replicon chromosome
Accession NZ_CP082967
Organism Klebsiella pneumoniae strain BD-41

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K9F23_RS13940 Protein ID WP_004184027.1
Coordinates 2795525..2796847 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K9F23_RS13945 Protein ID WP_004176198.1
Coordinates 2796847..2797113 (-) Length 89 a.a.

Genomic Context


K9F23_RS13925K9F23_RS13930K9F23_RS13935K9F23_RS13965K9F23_RS13940K9F23_RS13945K9F23_RS13950K9F23_RS13955K9F23_RS13960K9F23_RS13970
Location: 2790581..2793082 (2502 bp)
Type: Others
Protein ID: WP_032418977.1
Location: 2793070..2794074 (1005 bp)
Type: Others
Protein ID: WP_016946380.1
Location: 2794216..2795508 (1293 bp)
Type: Others
Protein ID: WP_002904794.1
Location: 2799905..2801059 (1155 bp)
Type: Others
Protein ID: WP_002904783.1
Location: 2795525..2796847 (1323 bp)
Type: Toxin
Protein ID: WP_004184027.1
Location: 2796847..2797113 (267 bp)
Type: Antitoxin
Protein ID: WP_004176198.1
Location: 2797379..2797705 (327 bp)
Type: Others
Protein ID: WP_004215084.1
Location: 2797702..2798202 (501 bp)
Type: Others
Protein ID: WP_032418978.1
Location: 2798180..2799559 (1380 bp)
Type: Others
Protein ID: WP_032418979.1
Location: 2801040..2801963 (924 bp)
Type: Others
Protein ID: WP_032418980.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K9F23_RS13925 (2790581)2790581..2793082+2502WP_032418977.1fimbria/pilus outer membrane usher protein-
K9F23_RS13930 (2793070)2793070..2794074+1005WP_016946380.1fimbrial protein-
K9F23_RS13935 (2794216)2794216..2795508+1293WP_002904794.1glycoside hydrolase family 10 protein-
K9F23_RS13940 (2795525)2795525..2796847-1323WP_004184027.1type II toxin-antitoxin system HipA family toxinToxin
K9F23_RS13945 (2796847)2796847..2797113-267WP_004176198.1type II toxin-antitoxin system antitoxin HipBAntitoxin
K9F23_RS13950 (2797379)2797379..2797705-327WP_004215084.1hydroxyisourate hydrolase-
K9F23_RS13955 (2797702)2797702..2798202-501WP_032418978.12-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase-
K9F23_RS13960 (2798180)2798180..2799559-1380WP_032418979.1nucleobase:cation symporter-2 family protein-
K9F23_RS13965 (2799905)2799905..2801059+1155WP_002904783.1FAD-dependent urate hydroxylase HpxO-
K9F23_RS13970 (2801040)2801040..2801963-924WP_032418980.1LysR family hpxDE operon transcriptional regulator HpxR-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(149-402)

Antitoxin

(13-65)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T215728 WP_004184027.1 NZ_CP082967:c2796847-2795525 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T215728 NZ_CP110933:14971-15369 [Salmonella enterica]
ATGCTGAAGTTTATGCTGGATACTAACATCTGCATTTTCACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCGGTCACCCTGATGGAGCTGATTTACGGTGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT215728 WP_004176198.1 NZ_CP082967:c2797113-2796847 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT215728 NZ_CP110933:14744-14971 [Salmonella enterica]
ATGGAAACCAGCGTATTTCTCAGTAACCGAAGTCAGGCGGTCAGACTGCCAAAAGCAGTGGCATTGCCGGAACATGTAAA
ACGTGTGGAAGTTATCGCTGTCGGGCGAACCCGGATCATCACGCCGGCCGGAGAATCGTGGGATGAATGGTTCGACGGGA
ACAACGTCAGCGCCGATTTTATGGATAACCGGGAACAACCCTCTGTGCAGGAACGGGAATCATTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
No matching records found

References