Detailed information of TA system TA215728

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2795525..2797113
• Replicon: chromosome
• Accession: NZ_CP082967
• Organism: Klebsiella pneumoniae strain BD-41

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K9F23_RS13940
• Protein ID: WP_004184027.1
• Coordinates: 2795525..2796847 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K9F23_RS13945
• Protein ID: WP_004176198.1
• Coordinates: 2796847..2797113 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9F23_RS13925 (2790581)	2790581..2793082	+	2502	WP_032418977.1	fimbria/pilus outer membrane usher protein	-
K9F23_RS13930 (2793070)	2793070..2794074	+	1005	WP_016946380.1	fimbrial protein	-
K9F23_RS13935 (2794216)	2794216..2795508	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
K9F23_RS13940 (2795525)	2795525..2796847	-	1323	WP_004184027.1	type II toxin-antitoxin system HipA family toxin	Toxin
K9F23_RS13945 (2796847)	2796847..2797113	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K9F23_RS13950 (2797379)	2797379..2797705	-	327	WP_004215084.1	hydroxyisourate hydrolase	-
K9F23_RS13955 (2797702)	2797702..2798202	-	501	WP_032418978.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
K9F23_RS13960 (2798180)	2798180..2799559	-	1380	WP_032418979.1	nucleobase:cation symporter-2 family protein	-
K9F23_RS13965 (2799905)	2799905..2801059	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
K9F23_RS13970 (2801040)	2801040..2801963	-	924	WP_032418980.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49139.47 Da
• Isoelectric Point: 7.5367

>T215728 WP_004184027.1 NZ_CP082967:c2796847-2795525 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T215728 NZ_CP110933:14971-15369 [Salmonella enterica]
ATGCTGAAGTTTATGCTGGATACTAACATCTGCATTTTCACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCGGTCACCCTGATGGAGCTGATTTACGGTGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT215728 WP_004176198.1 NZ_CP082967:c2797113-2796847 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT215728 NZ_CP110933:14744-14971 [Salmonella enterica]
ATGGAAACCAGCGTATTTCTCAGTAACCGAAGTCAGGCGGTCAGACTGCCAAAAGCAGTGGCATTGCCGGAACATGTAAA
ACGTGTGGAAGTTATCGCTGTCGGGCGAACCCGGATCATCACGCCGGCCGGAGAATCGTGGGATGAATGGTTCGACGGGA
ACAACGTCAGCGCCGATTTTATGGATAACCGGGAACAACCCTCTGTGCAGGAACGGGAATCATTCTGA