Detailed information of TA system TA021572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 4238780..4239466
• Replicon: chromosome
• Accession: NC_008009
• Organism: Candidatus Koribacter versatilis Ellin345

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: ACID345_RS18555
• Protein ID: WP_049761966.1
• Coordinates: 4238780..4239145 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: Q1IKL2
• Locus tag: ACID345_RS18560
• Protein ID: WP_011524387.1
• Coordinates: 4239149..4239466 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACID345_RS27025	4237194..4237583	+	390	WP_041855869.1	VOC family protein	-
ACID345_RS18550	4237599..4238483	-	885	WP_011524385.1	class I SAM-dependent methyltransferase	-
ACID345_RS18555	4238780..4239145	+	366	WP_049761966.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ACID345_RS18560	4239149..4239466	+	318	WP_011524387.1	helix-turn-helix domain-containing protein	Antitoxin
ACID345_RS18565	4239476..4240636	-	1161	WP_049761967.1	DUF1624 domain-containing protein	-
ACID345_RS18570	4240957..4242096	+	1140	WP_011524389.1	ferritin-like domain-containing protein	-
ACID345_RS18575	4242192..4242584	+	393	WP_011524390.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (20-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (15-94)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13984.33 Da
• Isoelectric Point: 10.5589

>T21572 WP_049761966.1 NC_008009:4238780-4239145 [Candidatus Koribacter versatilis Ellin345]
IWHSYLQWPLIFVADSRRCLLKFPQPVRHHIGFALYQAQMGGKHIDAKPLRGLSPGVMEVVSDHHGDTFRAVYTVRLANA
VYVLHAFQKKSKRGIATPQAEVELIKMRLRRAIEIDKQEER

Nucleotide

• Length: 366 bp

>T21572 NC_008009:4238780-4239145 [Candidatus Koribacter versatilis Ellin345]
ATCTGGCATAGTTATCTCCAGTGGCCTCTCATTTTCGTCGCGGACTCGCGTCGCTGCCTGCTTAAATTCCCGCAGCCGGT
TCGCCATCACATCGGTTTCGCGCTGTATCAGGCGCAGATGGGTGGGAAACACATTGACGCGAAGCCATTGAGAGGTCTCT
CGCCAGGCGTTATGGAGGTCGTATCGGACCATCACGGCGACACTTTTCGCGCGGTCTACACCGTGCGACTTGCAAATGCC
GTCTACGTCCTGCACGCGTTCCAGAAAAAGTCCAAGCGCGGAATTGCAACGCCGCAGGCAGAAGTTGAGCTAATCAAGAT
GCGCTTACGTCGCGCCATCGAGATCGACAAGCAAGAGGAGAGATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11437.44 Da
• Isoelectric Point: 11.1840

>AT21572 WP_011524387.1 NC_008009:4239149-4239466 [Candidatus Koribacter versatilis Ellin345]
MAKRNLDYTVSSGNIFADLGLPNSEELLAKAELANKISTLVGKRDLTQAQTAKLLGIDQPKVSALLRGKLSGFSIERLLR
FLLLLGHDVKITVQPARGRARVRVA

Nucleotide

• Length: 318 bp

>AT21572 NC_008009:4239149-4239466 [Candidatus Koribacter versatilis Ellin345]
ATGGCCAAGCGAAACCTCGACTACACCGTCAGTTCCGGAAACATCTTCGCCGACCTCGGCCTTCCTAACTCCGAAGAACT
GCTTGCCAAGGCCGAACTTGCGAACAAGATCTCGACTCTCGTCGGTAAGCGAGATCTCACCCAAGCCCAAACCGCCAAAC
TTCTTGGCATAGACCAACCGAAAGTCTCCGCCTTGCTCCGAGGCAAGCTCTCCGGCTTTTCCATCGAGCGCCTGCTGCGC
TTCCTGCTTTTGCTCGGCCACGACGTAAAGATCACCGTCCAACCCGCGCGCGGCCGCGCCCGTGTACGTGTCGCTTAA

Structures

Antitoxin

• AlphaFold DB: Q1IKL2