Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 798659..799316 Replicon chromosome
Accession NZ_CP082967
Organism Klebsiella pneumoniae strain BD-41

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K9F23_RS04000 Protein ID WP_002916310.1
Coordinates 798906..799316 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K9F23_RS03995 Protein ID WP_002916312.1
Coordinates 798659..798925 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F23_RS03970 (793815) 793815..795248 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
K9F23_RS03975 (795367) 795367..796095 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K9F23_RS03980 (796145) 796145..796456 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K9F23_RS03985 (796620) 796620..797279 + 660 WP_002916317.1 hemolysin III family protein -
K9F23_RS03990 (797430) 797430..798413 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K9F23_RS03995 (798659) 798659..798925 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K9F23_RS04000 (798906) 798906..799316 + 411 WP_002916310.1 protein YgfX Toxin
K9F23_RS04005 (799323) 799323..799844 - 522 WP_004144730.1 flavodoxin FldB -
K9F23_RS04010 (799945) 799945..800841 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K9F23_RS04015 (800864) 800864..801577 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9F23_RS04020 (801583) 801583..803316 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T215718 WP_002916310.1 NZ_CP082967:798906-799316 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T215718 NZ_CP110931:308524-308892 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
TATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT215718 WP_002916312.1 NZ_CP082967:798659-798925 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT215718 NZ_CP110931:308306-308527 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References