215715

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1088909..1089402 Replicon chromosome
Accession NZ_CP082963
Organism Enterococcus lactis strain HJS001

Toxin (Protein)


Gene name relE Uniprot ID A0A133MTG0
Locus tag K8Z62_RS05330 Protein ID WP_002329323.1
Coordinates 1089136..1089402 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag K8Z62_RS05325 Protein ID WP_002329324.1
Coordinates 1088909..1089139 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8Z62_RS05300 (K8Z62_05290) 1084981..1085748 + 768 WP_002329331.1 MurR/RpiR family transcriptional regulator -
K8Z62_RS05305 (K8Z62_05295) 1085749..1086192 + 444 WP_002329330.1 hypothetical protein -
K8Z62_RS05310 (K8Z62_05300) 1086364..1086992 - 629 Protein_1051 glutamine amidotransferase -
K8Z62_RS05315 (K8Z62_05305) 1087780..1088085 + 306 WP_002329327.1 hypothetical protein -
K8Z62_RS05320 (K8Z62_05310) 1088098..1088433 + 336 WP_002329326.1 hypothetical protein -
K8Z62_RS05325 (K8Z62_05315) 1088909..1089139 + 231 WP_002329324.1 DUF6290 family protein Antitoxin
K8Z62_RS05330 (K8Z62_05320) 1089136..1089402 + 267 WP_002329323.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8Z62_RS05335 (K8Z62_05325) 1089654..1089881 + 228 WP_002329322.1 hypothetical protein -
K8Z62_RS05340 (K8Z62_05330) 1089897..1091063 + 1167 WP_002329321.1 radical SAM family heme chaperone HemW -
K8Z62_RS05345 (K8Z62_05335) 1091297..1092340 + 1044 WP_002329320.1 heat-inducible transcriptional repressor HrcA -
K8Z62_RS05350 (K8Z62_05340) 1092434..1092997 + 564 WP_002292135.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10617.27 Da        Isoelectric Point: 10.1925

>T215715 WP_002329323.1 NZ_CP082963:1089136-1089402 [Enterococcus lactis]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Download         Length: 267 bp

>T215715 NZ_CP110921:c3054573-3054406 [Methylococcus sp. 16-5]
GTGATCCTGGTCGATACTTCGATCTGGATAGATCACTTTCGCGCCGGCGATCCGCTGTTGGCGGAATTGCTGAACGACCG
CCGCGTCTTAGCCCATCCTTTCGTTGCCGGCGAGTTGGCATGTGGCAACCTCAAGAACCGGGCGTCGATCTTGTCCCTTT
TCCGGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT215715 WP_002329324.1 NZ_CP082963:1088909-1089139 [Enterococcus lactis]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp

>AT215715 NZ_CP110921:c3054767-3054570 [Methylococcus sp. 16-5]
ATGCGGACTACATTGAATATTGACGATCGCTTGTTGGCCGAAGCCCAGCGTATGACCGGTCTGGTGGAAAAATCGGTCTT
GGTACGGGAGGGGCTCAAAGCCCTGGTCGAACGGGAAAGCGCGCGGCGCCTCGCGCTGCTGGCTGGCAGCGAACCCCAGT
TGCAAAATATCCCCCGCCGCCAAACGGAACCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133MTG0

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References