Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 222976..224599 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP082955 | ||
| Organism | Salmonella enterica subsp. arizonae strain S499 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | H9TH67 |
| Locus tag | K8I78_RS24710 | Protein ID | WP_000088046.1 |
| Coordinates | 223274..224599 (+) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
| Locus tag | K8I78_RS24705 | Protein ID | WP_024136327.1 |
| Coordinates | 222976..223269 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8I78_RS24680 (K8I78_24520) | 218848..220089 | + | 1242 | WP_001053338.1 | VWA domain-containing protein | - |
| K8I78_RS27365 | 220180..220311 | + | 132 | WP_000374059.1 | hypothetical protein | - |
| K8I78_RS24685 (K8I78_24525) | 220652..220933 | - | 282 | WP_000077926.1 | hypothetical protein | - |
| K8I78_RS24690 (K8I78_24530) | 220983..221174 | - | 192 | WP_000398480.1 | hypothetical protein | - |
| K8I78_RS24695 (K8I78_24535) | 221266..221607 | - | 342 | WP_001151575.1 | hypothetical protein | - |
| K8I78_RS24700 (K8I78_24540) | 221980..222372 | + | 393 | WP_000341066.1 | hypothetical protein | - |
| K8I78_RS24705 (K8I78_24545) | 222976..223269 | + | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| K8I78_RS24710 (K8I78_24550) | 223274..224599 | + | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| K8I78_RS24715 (K8I78_24555) | 224660..224866 | + | 207 | WP_000134171.1 | hypothetical protein | - |
| K8I78_RS24720 (K8I78_24560) | 224968..225378 | + | 411 | WP_000985911.1 | hypothetical protein | - |
| K8I78_RS24725 (K8I78_24565) | 225391..226206 | + | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
| K8I78_RS24730 (K8I78_24570) | 226460..226885 | + | 426 | WP_001043843.1 | hypothetical protein | - |
| K8I78_RS24735 (K8I78_24575) | 227434..227742 | + | 309 | WP_001224687.1 | hypothetical protein | - |
| K8I78_RS24740 (K8I78_24580) | 227758..228615 | + | 858 | WP_000784387.1 | HNH endonuclease signature motif containing protein | - |
| K8I78_RS24745 (K8I78_24585) | 228677..228880 | + | 204 | WP_001194555.1 | hypothetical protein | - |
| K8I78_RS24750 (K8I78_24590) | 229222..229578 | - | 357 | WP_065311124.1 | H-NS family nucleoid-associated regulatory protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | mph(A) / msr(E) / mph(E) / erm(B) / sul1 / qacE / ARR-3 / aac(6')-Ib-cr / blaCTX-M-55 / blaTEM-1B / aph(3')-Ia | - | 1..250265 | 250265 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T215703 WP_000088046.1 NZ_CP082955:223274-224599 [Salmonella enterica subsp. arizonae]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
>T215703 NZ_CP110895:c343-77 [Citrobacter freundii]
TTGGTCTGGACGATTAACTATTCCGACCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGGATTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCATTCTGTGTGAGATCCGGGATGACGAGCTGGTTATCCTTGCCGCCACCATT
GGCCATCGCCGCGAAGTTTACGACTGA
TTGGTCTGGACGATTAACTATTCCGACCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGGATTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCATTCTGTGTGAGATCCGGGATGACGAGCTGGTTATCCTTGCCGCCACCATT
GGCCATCGCCGCGAAGTTTACGACTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT215703 WP_024136327.1 NZ_CP082955:222976-223269 [Salmonella enterica subsp. arizonae]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
>AT215703 NZ_CP110895:c551-327 [Citrobacter freundii]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
CTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAAGATTATTATCTTTCAGCAGAAACTGCCGCACGCGTTC
GCCGTGGTGATGAAGCCGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
CTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAAGATTATTATCTTTCAGCAGAAACTGCCGCACGCGTTC
GCCGTGGTGATGAAGCCGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3T0VBU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z6V2D1 |