Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3678002..3678622 Replicon chromosome
Accession NZ_CP082954
Organism Salmonella enterica subsp. arizonae strain S499

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag K8I78_RS17755 Protein ID WP_001280991.1
Coordinates 3678404..3678622 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag K8I78_RS17750 Protein ID WP_000344807.1
Coordinates 3678002..3678376 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8I78_RS17740 (3673139) 3673139..3674332 + 1194 WP_023246703.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K8I78_RS17745 (3674355) 3674355..3677504 + 3150 WP_023246702.1 efflux RND transporter permease AcrB -
K8I78_RS17750 (3678002) 3678002..3678376 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
K8I78_RS17755 (3678404) 3678404..3678622 + 219 WP_001280991.1 HHA domain-containing protein Toxin
K8I78_RS17760 (3678802) 3678802..3679353 + 552 WP_053508533.1 maltose O-acetyltransferase -
K8I78_RS17765 (3679470) 3679470..3679940 + 471 WP_023246700.1 YlaC family protein -
K8I78_RS17770 (3679995) 3679995..3680135 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
K8I78_RS17775 (3680141) 3680141..3680401 - 261 WP_023182818.1 type B 50S ribosomal protein L31 -
K8I78_RS17780 (3680626) 3680626..3682176 + 1551 WP_053508537.1 EAL domain-containing protein -
K8I78_RS17790 (3682407) 3682407..3682796 + 390 WP_023246698.1 MGMT family protein -
K8I78_RS17795 (3682829) 3682829..3683398 - 570 WP_088760152.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T215700 WP_001280991.1 NZ_CP082954:3678404-3678622 [Salmonella enterica subsp. arizonae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T215700 NZ_CP110894:c4220853-4220446 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGTTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT215700 WP_000344807.1 NZ_CP082954:3678002-3678376 [Salmonella enterica subsp. arizonae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT215700 NZ_CP110894:c4221100-4220834 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References