Detailed information of TA system TA021570

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2503448..2504050
• Replicon: chromosome
• Accession: NC_008009
• Organism: Candidatus Koribacter versatilis Ellin345

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ACID345_RS26300
• Protein ID: WP_011522891.1
• Coordinates: 2503448..2503750 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q1IPV9
• Locus tag: ACID345_RS10755
• Protein ID: WP_011522892.1
• Coordinates: 2503754..2504050 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACID345_RS10730	2499246..2500286	-	1041	WP_011522887.1	glycosyltransferase family 4 protein	-
ACID345_RS10735	2500289..2501077	-	789	WP_011522888.1	PIG-L family deacetylase	-
ACID345_RS10740	2501147..2501983	+	837	WP_011522889.1	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	-
ACID345_RS10745	2501937..2503451	+	1515	WP_083763716.1	cation:dicarboxylase symporter family transporter	-
ACID345_RS26300	2503448..2503750	-	303	WP_011522891.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ACID345_RS10755	2503754..2504050	-	297	WP_011522892.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ACID345_RS10760	2504116..2504817	-	702	WP_041855620.1	EcsC family protein	-
ACID345_RS10765	2504929..2506599	+	1671	WP_011522894.1	ribonuclease J	-
ACID345_RS10770	2506596..2506988	+	393	WP_011522895.1	hypothetical protein	-
ACID345_RS10775	2507005..2507541	+	537	WP_011522896.1	PH domain-containing protein	-
ACID345_RS10780	2507585..2508802	+	1218	WP_049761859.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-53)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11505.00 Da
• Isoelectric Point: 3.8831

>T21570 WP_011522891.1 NC_008009:c2503750-2503448 [Candidatus Koribacter versatilis Ellin345]
MELEWSTFAMADRETIFDYIEAESPQNAVLVDDRIETQIEMLVQFPESGRQGRVEGTRELVVELTPFIVAYRIEVDCVRI
LRVLNGAQQWPDVMPEDSAT

Nucleotide

• Length: 303 bp

>T21570 NC_008009:c2503750-2503448 [Candidatus Koribacter versatilis Ellin345]
ATGGAGTTGGAATGGTCAACCTTTGCGATGGCGGATCGTGAAACGATCTTTGATTACATCGAAGCAGAGAGCCCGCAAAA
CGCGGTGCTGGTTGATGATCGCATCGAGACGCAAATCGAAATGCTGGTTCAATTCCCAGAAAGCGGCCGACAAGGTCGAG
TTGAAGGCACTCGAGAGCTGGTAGTCGAGCTTACGCCCTTCATCGTTGCGTACCGAATCGAGGTTGATTGCGTGCGGATA
TTGCGTGTATTGAACGGCGCGCAACAGTGGCCGGATGTCATGCCCGAGGACTCCGCGACCTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10822.58 Da
• Isoelectric Point: 11.1587

>AT21570 WP_011522892.1 NC_008009:c2504050-2503754 [Candidatus Koribacter versatilis Ellin345]
MLSSALVQTRIDPVVKERAAAVLEKSGLTVSDAVRILLTRIANEGALPFVLKDESPAHDAWFRAKVQEALADGRAAVPHE
QVKKHFAKRRQTALRKAR

Nucleotide

• Length: 297 bp

>AT21570 NC_008009:c2504050-2503754 [Candidatus Koribacter versatilis Ellin345]
ATGCTTTCGAGCGCTCTGGTACAAACCCGAATCGATCCTGTTGTGAAGGAACGGGCGGCAGCCGTGTTGGAGAAGTCCGG
CCTCACCGTGTCAGATGCAGTGCGCATTTTGCTGACCCGGATCGCAAACGAAGGGGCACTGCCATTCGTGTTGAAGGACG
AAAGCCCCGCCCACGACGCCTGGTTTCGCGCTAAAGTGCAAGAGGCACTGGCCGATGGCCGCGCCGCTGTACCCCATGAA
CAGGTGAAGAAGCATTTTGCGAAGCGACGCCAGACGGCGCTGCGCAAGGCCCGCTGA

Structures

Antitoxin

• AlphaFold DB: Q1IPV9