Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1966860..1967469 Replicon chromosome
Accession NZ_CP082954
Organism Salmonella enterica subsp. arizonae strain S499

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K8I78_RS09390 Protein ID WP_023222895.1
Coordinates 1966860..1967039 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K8I78_RS09395 Protein ID WP_023222894.1
Coordinates 1967068..1967469 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8I78_RS09350 (1962420) 1962420..1962644 - 225 WP_000106483.1 DUF2594 family protein -
K8I78_RS09355 (1962641) 1962641..1962796 - 156 WP_023248833.1 hypothetical protein -
K8I78_RS09360 (1963108) 1963108..1963764 + 657 WP_023248832.1 UvrY/SirA/GacA family response regulator transcription factor -
K8I78_RS09365 (1963761) 1963761..1965593 + 1833 WP_088759822.1 excinuclease ABC subunit UvrC -
K8I78_RS09370 (1965650) 1965650..1966198 + 549 WP_001160192.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
K8I78_RS09390 (1966860) 1966860..1967039 + 180 WP_023222895.1 type II toxin-antitoxin system HicA family toxin Toxin
K8I78_RS09395 (1967068) 1967068..1967469 + 402 WP_023222894.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K8I78_RS09400 (1967722) 1967722..1968219 + 498 WP_023222893.1 hypothetical protein -
K8I78_RS09405 (1968317) 1968317..1968586 - 270 WP_023222892.1 ogr/Delta-like zinc finger family protein -
K8I78_RS09410 (1968629) 1968629..1969774 - 1146 WP_182382413.1 phage late control D family protein -
K8I78_RS09415 (1969777) 1969777..1970301 - 525 WP_182382414.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliA 1956545..1990605 34060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6617.83 Da        Isoelectric Point: 10.9132

>T215691 WP_023222895.1 NZ_CP082954:1966860-1967039 [Salmonella enterica subsp. arizonae]
MDSRSAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T215691 NZ_CP110894:261862-262137 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATTAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14435.28 Da        Isoelectric Point: 4.1880

>AT215691 WP_023222894.1 NZ_CP082954:1967068-1967469 [Salmonella enterica subsp. arizonae]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDALESAREAIDAHLELLVEDGEAIPEATSVEKWLSDPDYDGVVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVTGL

Download         Length: 402 bp

>AT215691 NZ_CP110894:262134-262493 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTGATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References