Detailed information of TA system TA215690

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 896812..897472
• Replicon: chromosome
• Accession: NZ_CP082954
• Organism: Salmonella enterica subsp. arizonae strain S499

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8E9YGN6
• Locus tag: K8I78_RS04355
• Protein ID: WP_023249207.1
• Coordinates: 897059..897472 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A403SUT4
• Locus tag: K8I78_RS04350
• Protein ID: WP_063390801.1
• Coordinates: 896812..897078 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8I78_RS04330 (892753)	892753..894186	-	1434	WP_088759676.1	6-phospho-beta-glucosidase BglA	-
K8I78_RS04335 (894344)	894344..894655	+	312	WP_080169079.1	N(4)-acetylcytidine aminohydrolase	-
K8I78_RS04340 (894819)	894819..895478	+	660	WP_023249205.1	hemolysin III family protein	-
K8I78_RS04345 (895579)	895579..896559	-	981	WP_080169080.1	tRNA-modifying protein YgfZ	-
K8I78_RS04350 (896812)	896812..897078	+	267	WP_063390801.1	FAD assembly factor SdhE	Antitoxin
K8I78_RS04355 (897059)	897059..897472	+	414	WP_023249207.1	protein YgfX	Toxin
K8I78_RS04360 (897524)	897524..898045	-	522	WP_001055884.1	flavodoxin FldB	-
K8I78_RS04365 (898158)	898158..899054	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
K8I78_RS04370 (899078)	899078..899791	+	714	WP_023249209.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
K8I78_RS04375 (899797)	899797..901533	+	1737	WP_023249210.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16283.31 Da
• Isoelectric Point: 11.4501

>T215690 WP_023249207.1 NZ_CP082954:897059-897472 [Salmonella enterica subsp. arizonae]
VVLWQSELRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLRSGMVLRLRAESGHHQHLWLAADSMEAAEWRELRRIMLQQPISRQH

Nucleotide

• Length: 414 bp

>T215690 NZ_CP110893:1819-2133 [Citrobacter freundii]
ATGCAGTTCACTGTATACAGTAACACCGGAAAGAGCGCCGTCTATCCCCTACTGCTTGATGTAACCAGCGATATTATCGG
CCAGTTGAACCGCAGGATTGTGATCCCGCTGCTGCCTGTTGAAAAGTACCCTGGCAGCACTCGCCCGGAACGGCTGGTTC
CGCTTGTCAGACTGAACGACGGTAAAGAATATGCAGTTATGACGCATGAAATGGCGAGTATTCCCGCCCGTTCTCTGGGG
GCTGTGTTCTGCGATGCTTCCCTTCATCGTACCCAGGTTAAAGCCGCTATTGATTTTCTTCTAGACGGTATTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10578.10 Da
• Isoelectric Point: 6.0783

>AT215690 WP_063390801.1 NZ_CP082954:896812-897078 [Salmonella enterica subsp. arizonae]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPVDAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT215690 NZ_CP110893:1579-1815 [Citrobacter freundii]
ATGGCAACAACACAACGAGCAACACAAAGCGTTACTATGACCGTAGAACGTGCCTTACTCAGCCGTGCGCGTGAGGCTGG
TATTAATCTCAGTGCCACTCTGACCGCAGCCCTTGACGCTGAACTACGCCAGTATGAAGCGAAAAAATGGCAGGAGGAAA
ACAACGAAGCGCTGGAAGCGCTTAATCGTTTTCACGATGAACATGGTTGTTTCAGCGATGAGTACAGGACATTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A403SUT4